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Meta-Analysis
. 2019 Mar 26:2019:4015969.
doi: 10.1155/2019/4015969. eCollection 2019.

Prognostic Significance of MicroRNAs in Glioma: A Systematic Review and Meta-Analysis

Yanming Zhang  1 , Jigang Chen  2 , Qiang Xue  2 , Junyu Wang  2 , Liang Zhao  2 , Kaiwei Han  2 , Danfeng Zhang  2 , Lijun Hou  2
Affiliations
Meta-Analysis

Prognostic Significance of MicroRNAs in Glioma: A Systematic Review and Meta-Analysis

Yanming Zhang et al. Biomed Res Int. .

Abstract

Purpose: Different microRNAs (miRs) have been demonstrated to relate with the outcome of glioma patients, while the conclusions are inconsistent. We perform a meta-analysis to clarify the relationship between different miRs and prognosis of glioma.

Methods: Related studies were retrieved from PubMed, Embase, and Cochrane Library. Pooled hazard ratios (HRs) of different miRs expression for survival and 95% confidence intervals (CIs) were calculated using random-effects model.

Results: A total of 15 miRs with 4708 glioma patients were ultimately included. Increased expression of miR-15b (HR, 1.584; 95% CI, 1.199-2.092), 21 (HR, 1.591; 95% CI, 1.278-1.981), 148a (HR, 1.122; 95% CI, 1.023-1.231), 196 (HR, 1.877; 95% CI, 1.033-3.411), 210 (HR, 1.251; 95% CI, 1.010-1.550), and 221 (HR, 1.269; 95% CI, 1.054-1.527) or decreased expression of miR-106a (HR, 0.809; 95% CI, 0.655-0.998) and 124 (HR, 0.833; 95% CI, 0.729-0.952) was correlated with poor outcome of glioma patients.

Conclusions: miR-15b, 21, 148a, 196, 210, 221, 106a, and 124 are valuable biomarkers for the prognosis of glioma which might be used in clinical settings.

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Figures

Figure 1
Figure 1
Forest plots of miR-15b (a), 21 (b), 148a (c), 196 (d), 210 (e), and 221 (f) and glioma prognosis.
Figure 2
Figure 2
Forest plots of miR-106a (a) and 124 (b) and glioma prognosis.
Figure 3
Figure 3
Forest plots of miR-10b (a), 17 (b), 20a (c), 155 (d), 182 (e), 200b (f), and 222 (g) and glioma prognosis.
See this image and copyright information in PMC

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