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. 2019 Jun;2(1):6-13.
Epub 2019 Mar 18.

Recent Advances in the Development of Bio-Reducible Polymers for Efficient Cancer Gene Delivery Systems

Yong Kiel Sung  1   2 , Sung Wan Kim  1   2
Affiliations

Recent Advances in the Development of Bio-Reducible Polymers for Efficient Cancer Gene Delivery Systems

Yong Kiel Sung et al. Cancer Med J. 2019 Jun.

Abstract

Gene therapy is the unique method for the use of genetic materials such as Messenger ribonucleic acid (mRNA), plasmid deoxyribonucleic acid (pDNA), and small interfering ribonucleic acid (siRNA) into specific host-cells for the treatment of inherited disorders in any diseases. The successful way to utilize the gene therapy is to develop the efficient cancer gene delivery systems. In this paper, the successful and efficient gene delivery systems are briefly reviewed on the basis of bio-reducible polymeric systems for cancer therapy. The viral gene delivery systems such as RNA-based viral and DNA-based viral vectors are also discussed. The development of bio-reducible polymer for gene delivery system has briefly discussed for the efficient cancer gene delivery of viral vectors and non-viral vectors.

Keywords: Bio-reducible polymer; Cancer gene therapy; Gene delivery systems; PEI-conjugated polymer; RNA/DNA.

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References

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