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. 1987 Feb;19(1 Pt 3):2443-6.

OKT3 in the reversal of acute hepatic allograft rejection

C O Esquivel, J J Fung, B Markus, S Iwatsuki, R D Gordon, L Makowka, J W Marsh Jr, A G Tzakis, S Todo, T E Starzl

OKT3 in the reversal of acute hepatic allograft rejection

C O Esquivel et al. Transplant Proc. 1987 Feb.

Abstract

OKT3 was an effective immunosuppressant agent in patients with acute cell-mediated allograft rejection that had not responded to initial steroid therapy. OKT3 was also valuable for treating patients with early hepatic graft dysfunction caused by other factors than rejection. In such recipients, the doses of CyA can be greatly reduced, allowing recovery of frequently damaged kidneys while maintaining effective immunosuppression.

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Figures

Fig 1
Fig 1
Life-table analysis of graft survival in groups I and II (described in text) v control.
Fig 2
Fig 2
Life-table analysis of patient survival of the OKT3-treated group as compared with the control group.
See this image and copyright information in PMC

References

    1. Starzl TE, Iwatsuki S, Van Thiel DH, et al. Hepatology. 1982;2:614. - PMC - PubMed
    1. Cosmi AB, Colvin R, Burton R, et al. N Engl J Med. 1981;305:308. - PubMed
    1. Cosmi AB, Burton R, Colvin R, et al. Transplantation. 1981;32:535. - PubMed
    1. Fung JJ, Demetris AJ, Porter KA, et al. Nephron. (in press) - PMC - PubMed
    1. Starzl TE, Fung JJ. Transplant Proc. 1986;18:937. - PMC - PubMed

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