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. 2019 Jul;38(7):727-730.
doi: 10.1097/INF.0000000000002357.

Reducing Hematologic Toxicity With Short Course Postexposure Prophylaxis With Zidovudine for HIV-1 Exposed Infants With Low Transmission Risk

Thi Thanh Truc Nguyen  1 , Robin Kobbe  1 , Ulf Schulze-Sturm  1 , Martin Blohm  1 , Bettina Hollwitz  2 , Sandra Hertling  3 , Christina Becker  4 , Prasad Thomas Oommen  4 , Hans-Jürgen Laws  4 , Franca Martignoni  5 , Björn-Erik Ole Jensen  6 , Karen Olah  7 , Susanne Schmidtke  8 , Benno Kreuels  9 , Malte Kohns Vasconcelos  10 , Jennifer Neubert  4
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Reducing Hematologic Toxicity With Short Course Postexposure Prophylaxis With Zidovudine for HIV-1 Exposed Infants With Low Transmission Risk

Thi Thanh Truc Nguyen et al. Pediatr Infect Dis J. 2019 Jul.

Abstract

Using retrospectively collected data from 383 infants born to HIV-1-infected mothers receiving antiretroviral therapy, we compared transmission rates and hematologic toxicity between infants receiving 2-week (short course) versus longer duration zidovudine postexposure prophylaxis. Short course resulted in lower hematologic toxicity without evidence of increased vertical transmission risk.

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