A critique of the second consensus criteria for multiple system atrophy

Iva Stankovic^{1

2}, Niall Quinn³, Luca Vignatelli⁴, Angelo Antonini⁵, Daniela Berg^{6

7}, Elizabeth Coon⁸, Pietro Cortelli^{4

9}, Alessandra Fanciulli², Joaquim J Ferreira¹⁰, Roy Freeman¹¹, Glenda Halliday¹², Günter U Höglinger¹³, Valeria Iodice¹⁴, Horacio Kaufmann¹⁵, Thomas Klockgether¹⁶, Vladimir Kostic¹, Florian Krismer², Anthony Lang¹⁷, Johannes Levin¹⁸, Phillip Low⁸, Christopher Mathias^{19

20

21}, Wassillios G Meissner^{22

23}, Lucy Norcliffe Kaufmann¹⁵, Jose-Alberto Palma¹⁵, Jalesh N Panicker^{3

24}, Maria Teresa Pellecchia²⁵, Ryuji Sakakibara²⁶, Jeremy Schmahmann²⁷, Sonja W Scholz^{28

29}, Wolfgang Singer⁸, Maria Stamelou^{30

31}, Eduardo Tolosa³², Shoji Tsuji^{33

34}, Klaus Seppi², Werner Poewe², Gregor K Wenning²; Movement Disorder Society Multiple System Atrophy Study Group

Affiliations

¹ Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
² Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.
³ University College London, Institute of Neurology, Queen Square, London, UK.
⁴ Istituto di Ricovero e Cura a Carattere Scientifico, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
⁵ Department of Neuroscience, University of Padua, Padua, Italy.
⁶ Department of Neurology, Christian Albrecht University, Kiel, Germany.
⁷ Hertie Institute for Clinical Brain Research Tübingen, Tübingen, Germany.
⁸ Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
⁹ Dipartimento Scienze Biomediche e Neuromotorie, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
¹⁰ Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
¹¹ Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
¹² Brain and Mind Centre, Sydney Medical School, University of Sydney, Camperdown, Australia; School of Medical Sciences, University of New South Wales, Wales, Kensington, Australia; and Neuroscience Research Australia, Randwick, Australia.
¹³ Department of Neurology, Technische Universität München, and German Center for Neurodegenerative Diseases, München, Germany.
¹⁴ Autonomic Unit, National Hospital for Neurology and Neurosurgery, Queen Square/Division of Clinical Neurology, Institute of Neurology, University College London, London, UK.
¹⁵ Dysautonomia Center, Langone Medical Center, New York University School of Medicine, New York, New York, USA.
¹⁶ Department of Neurology, University of Bonn, and German Center for Neurodegenerative Diseases, Bonn, Germany.
¹⁷ Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
¹⁸ Department of Neurology, Ludwig-Maximilians-Universität München, and German Center for Neurodegenerative Diseases, München, Germany.
¹⁹ Autonomic and Neurovascular Medicine Centre, Hospital of St John & St Elizabeth, London, UK.
²⁰ Lindo Wing, Imperial College Healthcare National Health Service Trust, St Mary's Hospital, London, UK.
²¹ Queen Square Institute of Neurology, University College London, London, UK.
²² French Reference Center for MSA, Department of Neurology, University Hospital Bordeaux, Bordeaux, France.
²³ Institute of Neurodegenerative Disorders, University Bordeaux, Bordeaux, France.
²⁴ Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
²⁵ Center for Neurodegenerative Diseases, Department of Medicine and Surgery, Neuroscience Section, University of Salerno, Fisciano, Italy.
²⁶ Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan.
²⁷ Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
²⁸ Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
²⁹ Department of Neurology, Johns Hopkins University Medical Center, Baltimore, Maryland, USA.
³⁰ HYGEIA Hospital, Athens, Greece, Neurology Clinic, University Marburg, Marburg, Germany.
³¹ Department of Neurology, University of Athens, Athens, Greece.
³² Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.
³³ Department of Molecular Neurology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.
³⁴ International University of Health and Welfare, Chiba, Japan.

PMID: 31034671
PMCID: PMC6737532
DOI: 10.1002/mds.27701

A critique of the second consensus criteria for multiple system atrophy

Iva Stankovic et al. Mov Disord. 2019 Jul.

. 2019 Jul;34(7):975-984.

doi: 10.1002/mds.27701. Epub 2019 Apr 29.

Authors

Affiliations

¹ Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
² Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.
³ University College London, Institute of Neurology, Queen Square, London, UK.
⁴ Istituto di Ricovero e Cura a Carattere Scientifico, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
⁵ Department of Neuroscience, University of Padua, Padua, Italy.
⁶ Department of Neurology, Christian Albrecht University, Kiel, Germany.
⁷ Hertie Institute for Clinical Brain Research Tübingen, Tübingen, Germany.
⁸ Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
⁹ Dipartimento Scienze Biomediche e Neuromotorie, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
¹⁰ Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
¹¹ Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
¹² Brain and Mind Centre, Sydney Medical School, University of Sydney, Camperdown, Australia; School of Medical Sciences, University of New South Wales, Wales, Kensington, Australia; and Neuroscience Research Australia, Randwick, Australia.
¹³ Department of Neurology, Technische Universität München, and German Center for Neurodegenerative Diseases, München, Germany.
¹⁴ Autonomic Unit, National Hospital for Neurology and Neurosurgery, Queen Square/Division of Clinical Neurology, Institute of Neurology, University College London, London, UK.
¹⁵ Dysautonomia Center, Langone Medical Center, New York University School of Medicine, New York, New York, USA.
¹⁶ Department of Neurology, University of Bonn, and German Center for Neurodegenerative Diseases, Bonn, Germany.
¹⁷ Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
¹⁸ Department of Neurology, Ludwig-Maximilians-Universität München, and German Center for Neurodegenerative Diseases, München, Germany.
¹⁹ Autonomic and Neurovascular Medicine Centre, Hospital of St John & St Elizabeth, London, UK.
²⁰ Lindo Wing, Imperial College Healthcare National Health Service Trust, St Mary's Hospital, London, UK.
²¹ Queen Square Institute of Neurology, University College London, London, UK.
²² French Reference Center for MSA, Department of Neurology, University Hospital Bordeaux, Bordeaux, France.
²³ Institute of Neurodegenerative Disorders, University Bordeaux, Bordeaux, France.
²⁴ Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
²⁵ Center for Neurodegenerative Diseases, Department of Medicine and Surgery, Neuroscience Section, University of Salerno, Fisciano, Italy.
²⁶ Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan.
²⁷ Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
²⁸ Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
²⁹ Department of Neurology, Johns Hopkins University Medical Center, Baltimore, Maryland, USA.
³⁰ HYGEIA Hospital, Athens, Greece, Neurology Clinic, University Marburg, Marburg, Germany.
³¹ Department of Neurology, University of Athens, Athens, Greece.
³² Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.
³³ Department of Molecular Neurology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.
³⁴ International University of Health and Welfare, Chiba, Japan.

PMID: 31034671
PMCID: PMC6737532
DOI: 10.1002/mds.27701

No abstract available

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Conflict of interest statement

Relevant conflicts of interests/financial disclosures: Dr. Klockgether received fees from Biohaven for consulting services related to the application of the Scale for the assessment and rating of ataxia.

References

1. Fanciulli A, Wenning G. Multiple-system atrophy. N Engl J Med 2015;372(3):249–263. - PubMed
1. Wenning G, Ben-Shlomo Y, Hughes A, Daniel S, Lees A, Quinn N. What clinical features are most useful to distinguish definite multiple system atrophy from Parkinson’s disease? J Neurol Neurosurg Psychiatry 2000;68(4):434–440. - PMC - PubMed
1. Hughes AJ, Daniel SE, Ben-Shlomo Y, Lees AJ. The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain 2002;125(Pt 4):861–870. - PubMed
1. Quinn N Multiple system atrophy—the nature of the beast. J Neurol Neurosurg Psychiatry 1989;52(suppl):78–89. - PMC - PubMed
1. Gilman S, Low PA, Quinn N, et al. Consensus statement on the diagnosis of multiple system atrophy. J Neurol Sci 1999;163(1): 94–98. - PubMed

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A critique of the second consensus criteria for multiple system atrophy

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A critique of the second consensus criteria for multiple system atrophy

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Conflict of interest statement

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