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Review
. 2019 Apr 29;20(9):2104.
doi: 10.3390/ijms20092104.

Application of Acyzol in the Context of Zinc Deficiency and Perspectives

Gjumrakch Aliev  1   2   3 , Yi Li  4 , Vladimir N Chubarev  5 , Svetlana A Lebedeva  6 , Lidiya N Parshina  7 , Boris A Trofimov  8 , Susanna S Sologova  9 , Alfiya Makhmutova  10 , Marco F Avila-Rodriguez  11 , Sergey G Klochkov  12 , Pavel A Galenko-Yaroshevsky  13 , Vadim V Tarasov  14
Affiliations
Review

Application of Acyzol in the Context of Zinc Deficiency and Perspectives

Gjumrakch Aliev et al. Int J Mol Sci. .

Abstract

Zinc is one of the most important essential trace elements. It is involved in more than 300 enzyme systems and is an indispensable participant in many biochemical processes. Zinc deficiency causes a number of disorders in the human body, the main ones being the delay of growth and puberty, immune disorders, and cognitive dysfunctions. There are over two billion people in the world suffering from zinc deficiency conditions. Acyzol, a zinc-containing medicine, developed as an antidote against carbon monoxide poisoning, demonstrates a wide range of pharmacological activities: Anti-inflammatory, reparative, detoxifying, immunomodulatory, bacteriostatic, hepatoprotective, adaptogenic, antioxidant, antihypoxic, and cardioprotective. The presence of zinc in the composition of Acyzol suggests the potential of the drug in the treatment and prevention of zinc deficiency conditions, such as Prasad's disease, immune system pathology, alopecia, allergodermatoses, prostate dysfunction, psoriasis, stomatitis, periodontitis, and delayed mental and physical development in children. Currently, the efficiency of Acyzol in the cases of zinc deficiency is shown in a large number of experimental studies. So, Acyzol can be used as a highly effective drug for pharmacologic therapy of a wide range of diseases and conditions and it opens up new perspectives in the treatment and prevention of zinc deficiency conditions.

Keywords: Acyzol; carbon monoxide; pharmacological activity; zinc; zinc deficiency conditions.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structural formula of Acyzol.
Figure 2
Figure 2
Absorption spectra of blood smears before and after addition of Acyzol (registration using the method of bio-crystallization of Acyzol (1:1500 and 1:3000) with the blood) [with permission from 95]. Annotation: 1) absorption spectra of a blood smear of a healthy donor. 2) absorption spectra of a blood smear after supplementation of Acyzol.
Figure 3
Figure 3
Body weight and relative liver weight in CCl4-intoxicated rats and in animals treated with Acyzol and Silymarin. Notes: *—significant differences compared to intact animals at p < 0.05. Data are presented in % relative to the intact group, taken as 100%. Relative liver weight is expressed as liver weight, mg/100 g of body weight.
Figure 4
Figure 4
Liver function in CCl4-intoxicated rats and in animals treated with Acyzol and Silymarin. Notice. *—significant differences compared to intact animals at p < 0.05. group I—intact. group II received equivalent amount of distilled water. group III received Acyzol at a dose of 10 mg/kg diluted in water. group IV—received Silymarin at a dose of 100 mg/kg.
See this image and copyright information in PMC

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