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. 2019 Apr 27;11(5):967.
doi: 10.3390/nu11050967.

Flavonoids and the Risk of Gastric Cancer: An Exploratory Case-Control Study in the MCC-Spain Study

Facundo Vitelli Storelli  1 , Antonio José Molina  2 , Raul Zamora-Ros  3 , Tania Fernández-Villa  4 , Vasiliki Roussou  5 , Dora Romaguera  6   7   8 , Nuria Aragonés  9   10 , Mireia Obón-Santacana  11   12   13 , Marcela Guevara  14   15 , Inés Gómez-Acebo  16   17 , Guillermo Fernández-Tardón  18   19 , Ana Molina-Barceló  20 , Rocío Olmedo-Requena  21   22 , Rocío Capelo  23 , María Dolores Chirlaque  24   25 , Beatriz Pérez-Gómez  26   27 , Victor Moreno  28   29   30   31 , Jesús Castilla  32   33 , María Rubín-García  34 , Marina Pollán  35   36 , Manolis Kogevinas  37   38   39   40 , Juan Pablo Barrio Lera  41 , Vicente Martín  42   43
Affiliations

Flavonoids and the Risk of Gastric Cancer: An Exploratory Case-Control Study in the MCC-Spain Study

Facundo Vitelli Storelli et al. Nutrients. .

Abstract

Several epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating the relationship between the different classes of flavonoids and the histological types and origin of GC can be of interest to the research community. We used data from a population-based multi-case control study (MCC-Spain) obtained from 12 different regions of Spain. 2700 controls and 329 GC cases were included in this study. Odds ratios (ORs) were calculated using the mixed effects logistic regression considering quartiles of flavonoid intakes and log2. Flavonoid intake was associated with a lower GC risk (ORlog2 = 0.76; 95% CI = 0.65-0.89; ORq4vsq1 = 0.60; 95%CI = 0.40-0.89; ptrend = 0.007). Inverse and statistically significant associations were observed with anthocyanidins, chalcones, dihydroflavonols and flavan-3-ols. The isoflavanoid intake was positively associated with higher cancer risk, but without reaching a statistical significance. In general, no differences were observed in the GC risk according to the location and histological type. The flavonoid intake seems to be a protective factor against GC within the MCC-study. This effect may vary depending on the flavonoid class but not by the histological type and location of the tumor. Broader studies with larger sample size and greater geographical variability are necessary.

Keywords: MCC-Spain; case-control study; flavonoids; gastric cancer; intake.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Algorithm for selection of controls and cases.
Figure 2
Figure 2
Gastric cancer (GC) risk according to flavonoids intakes in the multi-case control (MCC-Spain) study.
See this image and copyright information in PMC

References

    1. Diet, Nutrition, Physical Activity and Cancer: A Global Perspective. [(accessed on 24 December 2018)]; Available online: https://www.wcrf.org/sites/default/files/Summary-third-expert-report.pdf.
    1. Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2019. CA Cancer J. Clin. 2019;69:7–34. doi: 10.3322/caac.21551. - DOI - PubMed
    1. Allemani C., Matsuda T., Di Carlo V., Harewood R., Matz M., Niksic M., Bonaventure A., Valkov M., Johnson C.J., Esteve J., et al. Global surveillance of trends in cancer survival 2000-14 (concord-3): Analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 2018;391:1023–1075. doi: 10.1016/S0140-6736(17)33326-3. - DOI - PMC - PubMed
    1. Turati F., Rossi M., Pelucchi C., Levi F., La Vecchia C. Fruit and vegetables and cancer risk: A review of southern european studies. Br. J. Nutr. 2015;113:S102–S110. doi: 10.1017/S0007114515000148. - DOI - PubMed
    1. van Duijnhoven F.J., Bueno-De-Mesquita H.B., Ferrari P., Jenab M., Boshuizen H.C., Ros M.M., Casagrande C., Tjonneland A., Olsen A., Overvad K., et al. Fruit, vegetables, and colorectal cancer risk: The european prospective investigation into cancer and nutrition. Am. J. Clin. Nutr. 2009;89:1441–1452. doi: 10.3945/ajcn.2008.27120. - DOI - PubMed