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. 2019 Apr 29;19(1):123.
doi: 10.1186/s12877-019-1120-4.

Validation of Addenbrooke's cognitive examination III for detecting mild cognitive impairment and dementia in Japan

Shintaro Takenoshita  1 , Seishi Terada  2 , Hidenori Yoshida  1 , Megumi Yamaguchi  1 , Mayumi Yabe  1 , Nao Imai  1 , Makiko Horiuchi  1 , Tomoko Miki  1 , Osamu Yokota  1 , Norihito Yamada  1
Affiliations

Validation of Addenbrooke's cognitive examination III for detecting mild cognitive impairment and dementia in Japan

Shintaro Takenoshita et al. BMC Geriatr. .

Abstract

Background: Early detection of mild cognitive impairment (MCI) and dementia is very important to begin appropriate treatment promptly and to prevent disease exacerbation. We investigated the screening accuracy of the Japanese version of Addenbrooke's Cognitive Examination III (ACE-III) to diagnose MCI and dementia.

Methods: The original ACE-III was translated and adapted to Japanese. It was then administered to a Japanese population. The Hasegawa Dementia Scale-revised (HDS-R) and Mini-mental State Examination (MMSE) were also applied to evaluate cognitive dysfunction. In total, 389 subjects (dementia = 178, MCI = 137, controls = 73) took part in our study.

Results: The optimal ACE-III cut-off scores to detect MCI and dementia were 88/89 (sensitivity 0.77, specificity 0.92) and 75/76 (sensitivity 0.82, specificity 0.90), respectively. ACE-III was superior to HDS-R and MMSE in the detection of MCI or dementia. The internal consistency, test-retest reliability, and inter-rater reliability of ACE-III were excellent.

Conclusions: ACE-III is a useful cognitive test to detect MCI and dementia. ACE-III may be widely useful in clinical practice.

Keywords: Addenbrooke’s cognitive examination; Cognitive screening; Diagnosis dementia; Diagnosis mild cognitive impairment; Mild cognitive impairment.

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Conflict of interest statement

Ethics approval and consent to participate

This study adhered to the 1975 Helsinki Declaration of Human Rights. The Internal Ethical Committee of the Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences approved this study. We gave all participants written explanations of this research, taking into consideration the cognitive impairment of the participants. After a description of the study, written informed consent was obtained from the subjects who were able to express consent. In addition, written informed consent was obtained from their relatives in all cases.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Comparative AUROCs of tests for diagnosis of each condition. A (upper). ROC curves for discriminating MCI from controls using ACE-III, HDS-R, and MMSE. B (lower). ROC curves for discriminating dementia from non-dementia (controls and MCI), using ACE-III, HDS-R, and MMSE
See this image and copyright information in PMC

References

    1. Tomaszewski Farias S, Cahn-Weiner DA, Harvey DJ, Reed BR, Mungas D, Kramer JH, et al. Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults. Clin Neuropsychol. 2009;23:446–461. doi: 10.1080/13854040802360558. - DOI - PMC - PubMed
    1. Noone P. Addenbrooke's cognitive examination-III. Occup Med. 2015;65:418–420. doi: 10.1093/occmed/kqv041. - DOI - PubMed
    1. Lonie JA, Tierney KM, Ebmeier KP. Screening for mild cognitive impairment: a systematic review. International Journal of Geriatric Psychiatry. 2009;24:902–915. doi: 10.1002/gps.2208. - DOI - PubMed
    1. Mathuranath PS, Nestor PJ, Berrios GE, Rakowicz W, Hodges JR. A brief cognitive test battery to differentiate Alzheimer's disease and frontotemporal dementia. Neurology. 2000;55:1613–1620. doi: 10.1212/01.wnl.0000434309.85312.19. - DOI - PubMed
    1. Mioshi E, Dawson K, Mitchell J, Arnold R, Hodges JR. The Addenbrooke's cognitive examination revised (ACE-R): a brief cognitive test battery for dementia screening. International Journal of Geriatric Psychiatry. 2006;21:1078–1085. doi: 10.1002/gps.1610. - DOI - PubMed

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