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Comment
. 2019 Jun;19(6):305.
doi: 10.1038/s41568-019-0147-3.

Prioritizing synthetic lethal targets with functional genomics

Sarah Seton-Rogers  1
Affiliations
Comment

Prioritizing synthetic lethal targets with functional genomics

Sarah Seton-Rogers. Nat Rev Cancer. 2019 Jun.
No abstract available

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Comment on

  • Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability.
    Kategaya L, Perumal SK, Hager JH, Belmont LD. Kategaya L, et al. iScience. 2019 Mar 29;13:488-497. doi: 10.1016/j.isci.2019.02.006. Epub 2019 Mar 18. iScience. 2019. PMID: 30898619 Free PMC article.
  • Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
    Lieb S, Blaha-Ostermann S, Kamper E, Rippka J, Schwarz C, Ehrenhöfer-Wölfer K, Schlattl A, Wernitznig A, Lipp JJ, Nagasaka K, van der Lelij P, Bader G, Koi M, Goel A, Neumüller RA, Peters JM, Kraut N, Pearson MA, Petronczki M, Wöhrle S. Lieb S, et al. Elife. 2019 Mar 25;8:e43333. doi: 10.7554/eLife.43333. Elife. 2019. PMID: 30910006 Free PMC article.
  • WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
    Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li T, Zhang Y, Bin Liu J, Lazaro JB, Gu P, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D'Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ. Chan EM, et al. Nature. 2019 Apr;568(7753):551-556. doi: 10.1038/s41586-019-1102-x. Epub 2019 Apr 10. Nature. 2019. PMID: 30971823 Free PMC article.
  • Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
    Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ. Behan FM, et al. Nature. 2019 Apr;568(7753):511-516. doi: 10.1038/s41586-019-1103-9. Epub 2019 Apr 10. Nature. 2019. PMID: 30971826

References

Original articles
    1. Behan, F. M. et al. Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens. Nature https://doi.org/10.1038/s41586-019-1103-9 (2019) - DOI - PubMed
    1. Chan, E. M. et al. WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Nature https://doi.org/10.1038/s41586-019-1102-x (2019) - DOI - PubMed
    1. Kategaya, L. et al. Werner syndrome helicase is required for the survival of cancer cells with microsatellite instability. iScience https://doi.org/10.1016/j.isci.2019.02.006 (2019) - DOI - PubMed - PMC
    1. Lieb, S. et al. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells. eLife https://doi.org/10.7554/eLife.43333.001 (2019) - DOI - PubMed - PMC

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