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Review
. 2019 May;3(5):339-353.
doi: 10.1038/s41551-019-0392-5. Epub 2019 Apr 29.

A roadmap for the clinical implementation of optical-imaging biomarkers

Dale J Waterhouse  1   2 , Catherine R M Fitzpatrick  2   3 , Brian W Pogue  4 , James P B O'Connor  5 , Sarah E Bohndiek  6   7
Affiliations
Review

A roadmap for the clinical implementation of optical-imaging biomarkers

Dale J Waterhouse et al. Nat Biomed Eng. 2019 May.

Abstract

Clinical workflows for the non-invasive detection and characterization of disease states could benefit from optical-imaging biomarkers. In this Perspective, we discuss opportunities and challenges towards the clinical implementation of optical-imaging biomarkers for the early detection of cancer by analysing two case studies: the assessment of skin lesions in primary care, and the surveillance of patients with Barrett's oesophagus in specialist care. We stress the importance of technical and biological validations and clinical-utility assessments, and the need to address implementation bottlenecks. In addition, we define a translational roadmap for the widespread clinical implementation of optical-imaging technologies.

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References

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