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Review
. 2019 May;40(2):177-187.
doi: 10.1055/s-0039-1684046. Epub 2019 Apr 26.

Ototoxicity: Visualized in Concept Maps

Kelly L Watts  1   2
Affiliations
Review

Ototoxicity: Visualized in Concept Maps

Kelly L Watts. Semin Hear. 2019 May.

Abstract

Ototoxicity refers to the damage to structures and function of the auditory-vestibular system caused by exogenous agents such as pharmaceuticals, chemicals, and ionizing radiation. There are many potentially ototoxic substances. For example, depending on how ototoxicity is defined, there are 200 to 600 medications that can cause damage to hearing and/or balance. Ototoxicity encompasses cochleotoxicity, vestibulotoxicity, and neurotoxicity. A variety of professional disciplines are involved in determining causation, prevention, and management of ototoxic effects. Research to identify and develop otoprotectants and otorescue agents is emerging and will translate basic scientific discovery into applications for use in hearing conservation programs, safety operations, and clinical care. Original concept maps are presented here to visually represent knowledge pathways, domains, and relationships essential to the understanding of ototoxicity.

Keywords: concept map; ototoxicity; ototoxicity monitoring; ototoxins.

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Conflict of interest statement

CONFLICTS OF INTEREST The author has nothing to disclose.

Figures

Figure 1
Figure 1
What is the basis for knowledge of ototoxicity? This concept map explores knowledge areas that can provide the understanding needed to address the functional deficits due to ototoxicity.
Figure 2
Figure 2
What is ototoxicity? This concept map summarizes the knowledge areas comprising the basic definition for ototoxicity.
Figure 3
Figure 3
A Venn diagram of ototoxicity and neurotoxicity. Ototoxicity overlaps with neurotoxicity when there is involvement of the vestibulocochlear nerve and/or central auditory-vestibular nervous system.
Figure 4
Figure 4
What are the clinical effects of ototoxicity? This concept map describes symptoms of ototoxicity that the patient may experience and delves into why they may be important to the person's ability to function both in the immediate and long-term future.
Figure 5
Figure 5
What is an ototoxic agent? This concept map provides an overview of types of agents and concerns associated with those ototoxic agents.
Figure 6
Figure 6
Who is exposed to or administered an ototoxic agent? This concept map explores the person-centered factors to ototoxicity.
Figure 7
Figure 7
What is an ototoxicity monitoring program? This concept map shows the higher level details and components of an ototoxicity monitoring program. Knowledge areas regarding testing have not been included.
See this image and copyright information in PMC

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