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. 2019 Oct;103(2):156-159.
doi: 10.1016/j.jhin.2019.04.012. Epub 2019 Apr 27.

Screening for carbapenemase-producing Enterobacteriaceae in previous carriers readmitted to hospital: evaluation of a change in screening policy

A Tucker  1 , R George  2 , W Welfare  3 , P Cleary  4 , J Cawthorne  2 , A Dodgson  2
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Screening for carbapenemase-producing Enterobacteriaceae in previous carriers readmitted to hospital: evaluation of a change in screening policy

A Tucker et al. J Hosp Infect. 2019 Oct.

Abstract

Carbapenemase-producing Enterobacteriaceae (CPE) are a growing problem in UK hospitals. Preventing transmission requires early detection. This study evaluates a new screening policy for patients with a history of blaKPC-associated CPE (KPC-CPE) in a higher incidence hospital. Previous policy assumed 'once positive always positive'. New policy uses rapid screening and risk assessment. Results show that most (76.5%) patients with a history of KPC-CPE do not have detectable KPC-CPE on readmission or during their subsequent hospital stay but that repeat screening after an initial negative result is required. The new policy takes a risk-based approach while prioritizing isolation facilities in a higher incidence trust.

Keywords: Carbapenem-resistant Enterobacteriaceae; Carbapenemase-producing; Evaluation; Hospitals; Screening.

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