Rigorous Translational Models Are Key to Studying Ketamine's Antidepressant Mechanism: Response to Wang and Kaplin

Affiliations

¹ Department of Psychiatry and Behavioral Sciences (Williams, Blasey, Sudheimer, Rodriguez, Schatzberg) and Department of Anesthesiology, Perioperative, and Pain Medicine (Heifets), Stanford University, Stanford, Calif.

Comment

Boris D Heifets et al. Am J Psychiatry. 2019.

. 2019 May 1;176(5):412.

doi: 10.1176/appi.ajp.2019.19010044r.

¹ Department of Psychiatry and Behavioral Sciences (Williams, Blasey, Sudheimer, Rodriguez, Schatzberg) and Department of Anesthesiology, Perioperative, and Pain Medicine (Heifets), Stanford University, Stanford, Calif.

No abstract available

Keywords: Antidepressants; Depression; Drug Interactions; Ketamine; Naltrexone; Opioid.

Comment on

Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism.
Williams NR, Heifets BD, Blasey C, Sudheimer K, Pannu J, Pankow H, Hawkins J, Birnbaum J, Lyons DM, Rodriguez CI, Schatzberg AF. Williams NR, et al. Am J Psychiatry. 2018 Dec 1;175(12):1205-1215. doi: 10.1176/appi.ajp.2018.18020138. Epub 2018 Aug 29. Am J Psychiatry. 2018. PMID: 30153752 Free PMC article. Clinical Trial.
Explaining Naltrexone's Interference With Ketamine's Antidepressant Effect.
Wang M, Kaplin A. Wang M, et al. Am J Psychiatry. 2019 May 1;176(5):410-411. doi: 10.1176/appi.ajp.2019.19010044. Am J Psychiatry. 2019. PMID: 31039639 No abstract available.