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Comment
. 2019 Apr 30;116(18):8653-8654.
doi: 10.1073/pnas.1904017116.

Phototransduction gain at the G-protein, transducin, and effector protein, phosphodiesterase-6, stages in retinal rods

Martin Heck  1 , Klaus Peter Hofmann  1   2 , Timothy W Kraft  3 , Trevor D Lamb  4
Affiliations
Comment

Phototransduction gain at the G-protein, transducin, and effector protein, phosphodiesterase-6, stages in retinal rods

Martin Heck et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Comment in

Comment on

  • Elementary response triggered by transducin in retinal rods.
    Yue WWS, Silverman D, Ren X, Frederiksen R, Sakai K, Yamashita T, Shichida Y, Cornwall MC, Chen J, Yau KW. Yue WWS, et al. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5144-5153. doi: 10.1073/pnas.1817781116. Epub 2019 Feb 22. Proc Natl Acad Sci U S A. 2019. PMID: 30796193 Free PMC article.

References

    1. Yue WWS, et al. Elementary response triggered by transducin in retinal rods. Proc Natl Acad Sci USA. 2019;116:5144–5153. - PMC - PubMed
    1. Vuong TM, Chabre M, Stryer L. Millisecond activation of transducin in the cyclic nucleotide cascade of vision. Nature. 1984;311:659–661. - PubMed
    1. Heck M, Hofmann KP. Maximal rate and nucleotide dependence of rhodopsin-catalyzed transducin activation: Initial rate analysis based on a double displacement mechanism. J Biol Chem. 2001;276:10000–10009. - PubMed
    1. Qureshi BM, et al. It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods. Open Biol. 2018;8:180075. - PMC - PubMed
    1. Lamb TD, Heck M, Kraft TW. Implications of dimeric activation of PDE6 for rod phototransduction. Open Biol. 2018;8:180076. - PMC - PubMed

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