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. 2019 Apr 30;9(1):6679.
doi: 10.1038/s41598-019-43167-w.

Factors associated with chronic obstructive pulmonary disease exacerbation, based on big data analysis

Jongmin Lee  1 , Hyun Myung Jung  2 , Sook Kyung Kim  2 , Kwang Ha Yoo  3 , Ki-Suck Jung  4 , Sang Haak Lee  5 , Chin Kook Rhee  6
Affiliations

Factors associated with chronic obstructive pulmonary disease exacerbation, based on big data analysis

Jongmin Lee et al. Sci Rep. .

Abstract

Preventing exacerbation in chronic obstructive pulmonary disease (COPD) patients is crucial, but requires identification of the exacerbating factors. To date, no integrated analysis of patient-derived and external factors has been reported. To identify factors associated with COPD exacerbation, we collected data, including smoking status, lung function, and COPD assessment test scores, from 594 COPD patients in the Korean COPD subgroup study (KOCOSS), and merged these data with patients' Korean Health Insurance Review and Assessment Service data for 2007-2012. We also collected primary weather variables, including levels of particulate matter <10 microns in diameter, daily minimum ambient temperature, as well as respiratory virus activities, and the logs of web queries on COPD-related issues. We then assessed the associations between these patient-derived and external factors and COPD exacerbations. Univariate analysis showed that patient factors, air pollution, various types of viruses, temperature, and the number of COPD-related web queries were associated with COPD exacerbation. Multivariate analysis revealed that the number of exacerbations in the preceding year, female sex, COPD grade, and influenza virus detection rate, and lowest temperature showed significant association with exacerbation. Our findings may help COPD patients predict when exacerbations are likely, and provide intervention as early as possible.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Relationship between the lowest temperature and chronic obstructive pulmonary disease (COPD) acute exacerbation.
Figure 2
Figure 2
Correlation between PM10 and chronic obstructive pulmonary disease (COPD) acute exacerbation.
Figure 3
Figure 3
Relationship between the detection rate of virus and chronic obstructive pulmonary disease (COPD) acute exacerbation. (A) Relationship between influenza virus (IFV) and COPD acute exacerbation. (B) Relationship between human corona virus (hCoV) and COPD acute exacerbation. (C) Relationship between human rhinovirus (hRV) and COPD acute exacerbation.
Figure 4
Figure 4
Summary of results of this study: association between external patient-derived factors and chronic obstructive pulmonary disease (COPD) acute exacerbation. Reprinted with permission of the The Korea Academy of Tuberculosis and Respiratory Diseases. Copyright © The Korea Academy of Tuberculosis and Respiratory Diseases. Author (s)/Year/Title/ Pages.
See this image and copyright information in PMC

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