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Review
. 2016 Nov 30;8(5):123-126.
doi: 10.1002/cld.586. eCollection 2016 Nov.

How does the microbiome affect liver disease?

Herbert Tilg  1 , Christoph Grander  1 , Alexander R Moschen  1
Affiliations
Review

How does the microbiome affect liver disease?

Herbert Tilg et al. Clin Liver Dis (Hoboken). .
No abstract available

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Figures

Figure 1
Figure 1
In different hepatic diseases, like ALD, NAFLD, PSC, and cirrhosis, an impaired intestinal microbiota has been defined. Ethanol decreases the abundance of antimicrobial REG3 lectins and increases gut permeability. This results in increased translocation of lipopolysaccharides (LPS) and inflammatory responses. Cirrhosis is associated with dysbiosis (CDR) and increased translocation of different bacterial strains. Abbreviation: Tnf, tumor necrosis factor.
See this image and copyright information in PMC

References

    1. Mutlu EA, Gillevet PM, Rangwala H, Sikaroodi M, Naqvi A, Engen PA, et al. Colonic microbiome is altered in alcoholism. Am J Physiol Gastrointest Liver Physiol 2012;302:G966–G978. - PMC - PubMed
    1. Llopis M, Cassard AM, Wrzosek L, Boschat L, Bruneau A, Ferrere G, et al. Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease. Gut 2016;65:830–839. - PubMed
    1. Wang L, Fouts DE, Starkel P, Hartmann P, Chen P, Llorente C, et al. Intestinal REG3 lectins protect against alcoholic steatohepatitis by reducing mucosa‐associated microbiota and preventing bacterial translocation. Cell Host Microbe 2016;19:227–239. - PMC - PubMed
    1. Del Chierico F, Nobili V, Vernocchi P, Russo A, De Stefanis C, Gnani D, et al. Gut microbiota profiling of pediatric NAFLD and obese patients unveiled by an integrated meta‐omics based approach. Hepatology; doi:10.1002/hep.28572. - DOI - PubMed
    1. Boursier J, Mueller O, Barret M, Machado M, Fizanne L, Araujo‐Perez F, et al. The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology 2016;63:764–775. - PMC - PubMed