Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Mar 28;3(5):965-972.
doi: 10.1210/js.2019-00036. eCollection 2019 May 1.

Treatment of Central Precocious Puberty

Erica A Eugster  1
Affiliations
Review

Treatment of Central Precocious Puberty

Erica A Eugster. J Endocr Soc. .

Abstract

Long-acting analogs of GnRH (GnRHas) have been the gold-standard treatment of central precocious puberty (CPP) worldwide and have an enviable track record of safety and efficacy. Recent years have witnessed much growth in the availability of longer-acting and sustained-release forms of GnRHas. Although all available agents appear promising, limited long-term follow-up and/or comparative data are available. In this review, important issues pertaining to the treatment of children with CPP are discussed. In addition to an assessment of the newer extended-release GnRHa formulations, a delineation of factors essential in determining which children should be treated is offered. Outstanding uncertainties in clinical management are highlighted and areas in need of future research identified. Literature searches for this review were performed in PubMed and OVID, with a focus on English-language publications using the terms "central precocious puberty" and "treatment."

Keywords: GnRH analogs; precocious puberty; treatment.

PubMed Disclaimer

References

    1. Sultan C, Gaspari L, Maimoun L, Kalfa N, Paris F. Disorders of puberty. Best Pract Res Clin Obstet Gynaecol. 2018;48:62–89. - PubMed
    1. Comite F, Cutler GB, Jr, Rivier J, Vale WW, Loriaux DL, Crowley WF, Jr. Short-term treatment of idiopathic precocious puberty with a long-acting analogue of luteinizing hormone-releasing hormone. A preliminary report. N Engl J Med. 1981;305(26):1546–1550. - PubMed
    1. Belchetz PE, Plant TM, Nakai Y, Keogh EJ, Knobil E. Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone. Science. 1978;202(4368):631–633. - PubMed
    1. Swerdloff RS, Heber D. Superactive gonadotropin-releasing hormone agonists. Annu Rev Med. 1983; 34:491–500. - PubMed
    1. Aguirre RS, Eugster EA. Central precocious puberty: From genetics to treatment. Best Pract Res Clin Endocrinol Metab. 2018;32(4):343–354. - PubMed

LinkOut - more resources