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. 1978 Nov;14(11):939-44.
doi: 10.1007/BF02616124.

Effects of theophylline, epidermal chalone and x-irradiation on proliferation and differentiation of human keratinocytes in vitro

D P Chopra

Effects of theophylline, epidermal chalone and x-irradiation on proliferation and differentiation of human keratinocytes in vitro

D P Chopra. In Vitro. 1978 Nov.

Abstract

Outgrowth cultures of normal human epidermis were used to study a possible relationship between growth inhibition and differentiated function. The effects of theophylline, epidermal chalone and x-irradiation on mitoses and the characteristic production of epidermal keratohyaline granules (KG) were examined at various intervals after the treatment. Theophylline (an inhibitor of cyclic nucleotide phosphodiesterase) or epidermal chalone inhibited mitoses and enhanced KG production. X-irradiation inhibited mitoses but had no effect on KG formation. These results indicate that inhibition of proliferation per se is not sufficient to enhance keratinization of human epidermal cells.

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References

    1. J Invest Dermatol. 1967 Dec;49(6):595-604 - PubMed
    1. J Biol Chem. 1972 Nov 10;247(21):7082-7 - PubMed
    1. J Ultrastruct Res. 1972 Jan;38(1):16-26 - PubMed
    1. Natl Cancer Inst Monogr. 1973 Jul;38:47-59 - PubMed
    1. Cancer Res. 1965 Nov;25(10):1683-727 - PubMed

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