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. 1987 Jan;19(1):119-25.
doi: 10.1093/jac/19.1.119.

Chequerboard titrations: the influence of the composition of serial dilutions of antibiotics on the fractional inhibitory concentration index and fractional bactericidal concentration index

A M Horrevorts, C M de Ridder, M C Poot, M J de Jonge, J E Degener, G Dzoljic-Danilovic, M F Michel, K F Kerrebijn

Chequerboard titrations: the influence of the composition of serial dilutions of antibiotics on the fractional inhibitory concentration index and fractional bactericidal concentration index

A M Horrevorts et al. J Antimicrob Chemother. 1987 Jan.

Abstract

Chequerboard titrations carried out with modified serial dilutions of antibiotics such that consecutive concentrations in these series were four times smaller than those in two-fold serial dilutions enable MICs and MBCs to be determined with greater accuracy. Interaction indices calculated by this method can differ markedly from those calculated on the basis of two-fold serial dilutions. The differences calculated in this study ranged from -0.30 to +1.06.

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