2',3'-Dialdehyde of ATP: a specific, irreversible inhibitor of component A3 of the methylreductase system of Methanobacterium thermoautotrophicum
- PMID: 3104313
- PMCID: PMC212007
- DOI: 10.1128/jb.169.4.1737-1739.1987
2',3'-Dialdehyde of ATP: a specific, irreversible inhibitor of component A3 of the methylreductase system of Methanobacterium thermoautotrophicum
Abstract
Among 17 purine and ATP derivatives tested, 3 were found to totally inhibit the methyl coenzyme M methylreductase system of Methanobacterium thermoautotrophicum at a concentration of 5 mM; these derivatives were 8-azido-ATP, alpha, beta-thio-ADP and 2',3'-dialdehyde-ATP. 2',3'-Dialdehyde-ATP specifically and irreversibly bound to component A3 of the methylreductase system during ATP activation of the system.
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