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Review
. 2019 Jun;30(6):911-913.
doi: 10.1681/ASN.2019020160. Epub 2019 May 1.

Solving Baroreceptor Mystery: Role of PIEZO Ion Channels

Suzanne D Burke  1 , Jens Jordan  2 , David G Harrison  3 , S Ananth Karumanchi  4   5
Affiliations
Review

Solving Baroreceptor Mystery: Role of PIEZO Ion Channels

Suzanne D Burke et al. J Am Soc Nephrol. 2019 Jun.
No abstract available

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Figures

Figure 1.
Figure 1.
The arterial baroreflex controls arterial pressure and heart rate via connections between peripheral sensory ganglia and the nucleus tractus solitarius in the medulla. These afferent signals inhibit sympathetic outflow and increase parasympathetic output specifically to the heart and blood vessels, thereby triggering vasodilation and lowering BP by decreasing both heart rate and cardiac contractility. AV, atrioventricular; CN, cranial nerve; SA, sinoatrial.
Figure 2.
Figure 2.
Mechanical forces alter cation influx via PIEZO channels. Shear stress or compression change surface tension in the cell membrane to activate the PIEZO channel, which in turn, leads to increased intracellular cations and activation of downstream signaling.
See this image and copyright information in PMC

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