Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Jiyeon Kim¹, Zeping Hu¹, Ling Cai¹, Kailong Li¹, Eunhee Choi², Brandon Faubert¹, Divya Bezwada¹, Jaime Rodriguez-Canales³, Pamela Villalobos³, Yu-Fen Lin⁴, Min Ni¹, Kenneth E Huffman⁵, Luc Girard⁵, Lauren A Byers⁶, Keziban Unsal-Kacmaz⁷, Christopher G Peña^{8

9}, John V Heymach⁶, Els Wauters¹⁰, Johan Vansteenkiste¹⁰, Diego H Castrillon⁸, Benjamin P C Chen⁴, Ignacio Wistuba³, Diether Lambrechts^{11

12}, Jian Xu¹, John D Minna⁵, Ralph J DeBerardinis^{13

14

15}

Affiliations

¹ Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas, 75390, USA.
² Department of Pharmacology, UT Southwestern Medical Center, Dallas, Texas, 75390, USA.
³ Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, 2130 West Holcombe Boulevard, Houston, Texas, 77030, USA.
⁴ Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas, 75390, USA.
⁵ Hamon Center for Therapeutic Oncology, UT Southwestern Medical Center, Dallas, Texas, 75390, USA.
⁶ Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, 2130 West Holcombe Boulevard, Houston, Texas, 77030, USA.
⁷ Oncology Research Unit, Pfizer, 401 North Middletown Road, Pearl River, New York, 10965, USA.
⁸ Department of Pathology, UT Southwestern Medical Center, Dallas, Texas, 75390, USA.
⁹ University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas, 78229, USA.
¹⁰ Respiratory Division, University of Gasthuisberg, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
¹¹ Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, O&N 4 Herestraat 49 - box 912, 3000, Leuven, Belgium.
¹² VIB Center for Cancer Biology, KU Leuven, O&N 4 Herestraat 49 - box 912, 3000, Leuven, Belgium.
¹³ Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas, 75390, USA. Ralph.Deberardinis@UTSouthwestern.edu.
¹⁴ Department of Pediatrics, UT Southwestern Medical Center, Dallas, Texas, 75390, USA. Ralph.Deberardinis@UTSouthwestern.edu.
¹⁵ McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, Texas, 75390, USA. Ralph.Deberardinis@UTSouthwestern.edu.

PMID: 31043737
DOI: 10.1038/s41586-019-1133-3

Published Erratum

Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Jiyeon Kim et al. Nature. 2019 May.

. 2019 May;569(7756):E4.

doi: 10.1038/s41586-019-1133-3.

Authors

Affiliations

¹ Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas, 75390, USA.
² Department of Pharmacology, UT Southwestern Medical Center, Dallas, Texas, 75390, USA.
³ Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, 2130 West Holcombe Boulevard, Houston, Texas, 77030, USA.
⁴ Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas, 75390, USA.
⁵ Hamon Center for Therapeutic Oncology, UT Southwestern Medical Center, Dallas, Texas, 75390, USA.
⁶ Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, 2130 West Holcombe Boulevard, Houston, Texas, 77030, USA.
⁷ Oncology Research Unit, Pfizer, 401 North Middletown Road, Pearl River, New York, 10965, USA.
⁸ Department of Pathology, UT Southwestern Medical Center, Dallas, Texas, 75390, USA.
⁹ University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas, 78229, USA.
¹⁰ Respiratory Division, University of Gasthuisberg, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
¹¹ Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, O&N 4 Herestraat 49 - box 912, 3000, Leuven, Belgium.
¹² VIB Center for Cancer Biology, KU Leuven, O&N 4 Herestraat 49 - box 912, 3000, Leuven, Belgium.
¹³ Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas, 75390, USA. Ralph.Deberardinis@UTSouthwestern.edu.
¹⁴ Department of Pediatrics, UT Southwestern Medical Center, Dallas, Texas, 75390, USA. Ralph.Deberardinis@UTSouthwestern.edu.
¹⁵ McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, Texas, 75390, USA. Ralph.Deberardinis@UTSouthwestern.edu.

PMID: 31043737
DOI: 10.1038/s41586-019-1133-3

Abstract

Further analysis has revealed that the signal reported in Extended Data Fig. 1c of this Letter is attributed to phosphorylethanolamine, not carbamoyl phosphate. A newly developed derivatization method revealed that the level of carbamoyl phosphate in these NSCLC extracts is below the detection threshold of approximately 10 nanomoles. These findings do not alter the overall conclusions of the Letter; see associated Amendment for full details. The Letter has not been corrected online.

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Erratum for

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.
Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, Peña CG, Heymach JV, Wauters E, Vansteenkiste J, Castrillon DH, Chen BPC, Wistuba I, Lambrechts D, Xu J, Minna JD, DeBerardinis RJ. Kim J, et al. Nature. 2017 Jun 1;546(7656):168-172. doi: 10.1038/nature22359. Epub 2017 May 24. Nature. 2017. PMID: 28538732 Free PMC article.

References

1. Lowenstein, J. M. & Cohen, P. P. Studies on the biosynthesis of carbamylaspartic acid. J. Biol. Chem. 220, 57–70 (1956). - PubMed
1. Wang, Q., Xia, J., Guallar, V., Krilov, G. & Kantrowitz, E. R. Mechanism of thermal decomposition of carbamoyl phosphate and its stabilization by aspartate and ornithine transcarbamoylases. Proc. Natl Acad. Sci. USA 105, 16918–16923 (2008). - DOI
1. Haviv, F. et al. 3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: inhibitors of immune complex induced inflammation. J. Med. Chem. 31, 1719–1728 (1988). - DOI

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Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Affiliations

Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Authors

Affiliations

Abstract

Erratum for

References

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