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Case Reports
. 2019 Jan 23;12(1):104-108.
doi: 10.1159/000494753. eCollection 2019 Jan-Apr.

Hemolytic Anemia of Malignancy: A Case Study Involving Signet Ring Cell Metastatic Breast Cancer with Severe Microangiopathic Hemolytic Anemia

Eric H Lee  1 , Salman Otoukesh  1 , Amir Abdi Pour  2 , Gayathri Nagaraj  1
Affiliations
Case Reports

Hemolytic Anemia of Malignancy: A Case Study Involving Signet Ring Cell Metastatic Breast Cancer with Severe Microangiopathic Hemolytic Anemia

Eric H Lee et al. Case Rep Oncol. .

Abstract

Hemolytic anemia in the setting of malignancy is a rare manifestation of paraneoplastic syndrome with significant morbidity. Here we discuss a case involving metastatic breast cancer presenting with severe hemolytic anemia and renal failure secondary to thrombotic microangiopathy of malignancy. This case discusses the workup for secondary hemolytic anemia, a possible role for therapeutic plasma exchange in this setting, as well the current understanding of the management of microangiopathic hemolytic anemia of malignancy.

Keywords: Breast cancer; Hemolysis; Hemolytic anemia; Paraneoplastic; Plasma exchange.

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