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. 2019 Feb 8;9(1):66-76.
doi: 10.1159/000495107. eCollection 2019 Jan-Apr.

Validation of the Malay Version of Addenbrooke's Cognitive Examination III in Detecting Mild Cognitive Impairment and Dementia

Kwai Ching Kan  1 , Ponnusamy Subramaniam  1   2 , Nortina Shahrizaila  3 , Shahrul Bahyah Kamaruzzaman  4 , Rosdinom Razali  5 , Shazli Ezzat Ghazali  1
Affiliations

Validation of the Malay Version of Addenbrooke's Cognitive Examination III in Detecting Mild Cognitive Impairment and Dementia

Kwai Ching Kan et al. Dement Geriatr Cogn Dis Extra. .

Abstract

Background/aims: This study aimed to investigate the validity and reliability of the Malay version of Addenbrooke's Cognitive Examination III (ACE-III) for detecting mild cognitive impairment (MCI) and dementia.

Methods: A total of 152 participants (dementia = 53, MCI = 38, controls = 61) were recruited from two teaching hospitals. The Malay version of ACE-III was translated following the standard guidelines for cross-cultural adaptation of measure. All the participants were assessed with the Malay version of ACE-III and Mini-Mental State Examination (MMSE).

Results: The reliability of the Malay version of ACE-III was good with Cronbach's α coefficient of 0.829 and intraclass correlation coefficient of 0.959. There was a strong positive correlation between the Malay version of ACE-III and MMSE (r = 0.806). Age (r = -0.335) and years of education (r = 0.536) exerted a significant correlation with total score performance. The cutoff score to discriminate dementia from healthy controls was 74/75 (sensitivity = 90.6%, specificity = 82.0%) whereas to discriminate MCI, the cutoff score was 77/78 (sensitivity = 63.2%, specificity = 63.9%). The diagnostic accuracy of ACE-III was higher than that of MMSE in the detection of dementia (area under the curve: ACE-III = 0.929 vs. MMSE = 0.915).

Conclusions: The Malay version of ACE-III demonstrated to be a reliable and valid screening tool for dementia.

Keywords: Addenbrooke's Cognitive Examination III; Dementia; Malay language; Mild cognitive impairment.

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Figures

Fig. 1
Fig. 1
ROC curve of the ACE-III and MMSE for discriminating healthy controls from dementia patients.
Fig. 2
Fig. 2
ROC curve of the ACE-III and MMSE for discriminating healthy controls from MCI patients.
See this image and copyright information in PMC

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