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Comment
. 2019 Nov 13;69(11):2040-2042.
doi: 10.1093/cid/ciz348.

Reply to Hemmige and David

Eili Y Klein  1   2   3 , Katie K Tseng  3 , Oliver Gatalo  3 , Sara E Cosgrove  4
Affiliations
Comment

Reply to Hemmige and David

Eili Y Klein et al. Clin Infect Dis. .
No abstract available

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Figures

Figure 1.
Figure 1.
Comparison of different propensity score analyses of the excess cost of MRSA compared to MSSA hospitalizations by infection type, 2014–2016. The excess cost of MRSA-related hospitalizations, compared to MSSA-related hospitalizations, was measured as the mean cost of MRSA-related hospitalizations minus the mean cost of MSSA-related hospitalizations. The error bars are the 95% confidence intervals of the difference in the means, and negative values indicate that MRSA-related hospitalizations were, on average, less costly than similar MSSA-related hospitalizations. A, Estimated costs using a PSM algorithm accounting for LOS and numbers of procedures for 2014 (same as in the original paper) through 2016. B, Estimated cost without LOS and numbers of procedures in a PSM algorithm. C, Estimated costs for patients that were discharged alive with an LOS ≤ 10 days using a PSM algorithm including LOS and procedures for 2014 (same as in the original paper) through 2016. D, Estimated costs without LOS and number of procedures in a PSM algorithm for patients with an LOS ≤ 10. LOS was stratified as 0–7, 8–14, 15–20, and 21+ days to account for the endogeneity of infection risk in longer lengths of stay. Abbreviations: LOS, length of stay; MRSA, methicillin-resistant Staphylococcus aureus; MSSA, methicillin-susceptible Staphylococcus aureus; PSM, propensity score matching; S. aureus, Staphylococcus aureus.
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References

    1. Kourtis AP, Hatfield K, Baggs J, et al. . Vital signs: epidemiology and recent trends in methicillin-resistant and in methicillin-susceptible Staphylococcus aureus bloodstream infections — United States. MMWR Morb Mortal Wkly Rep 2019;68:214–9. Available at: http://www.cdc.gov/mmwr/volumes/68/wr/mm6809e1.htm?s_cid=mm6809e1_w - PMC - PubMed
    1. Klein EY, Mojica N, Jiang W, et al. . Trends in methicillin-resistant Staphylococcus aureus hospitalizations in the United States, 2010–2014. Clin Infect Dis. 2017; 65:1921–3. doi:10.1093/cid/cix640 - PubMed
    1. Klein EY, Jiang W, Mojica N, et al. . National costs associated with methicillin-susceptible and methicillin-resistant Staphylococcus aureus hospitalizations in the United States, 2010–2014. Clin Infect Dis 2019; 68:22–8. doi:10.1093/cid/ciy399 - PMC - PubMed
    1. Hemmige V, David MZ. Effects of including variables such as length of stay in a propensity score analysis with costs as outcome. Clin Infect Dis 2019; 69:2039–40. - PMC - PubMed
    1. Collins AS. Preventing health care–associated infections Available at: https://www.ncbi.nlm.nih.gov/books/NBK2683