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. 1987 Apr 1;165(4):1230-5.
doi: 10.1084/jem.165.4.1230.

The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain

I Funke, A Hahn, E P Rieber, E Weiss, G Riethmüller

The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain

I Funke et al. J Exp Med. .

Abstract

The expression of the CD4 antigen in normal human brain was investigated in parallel by immunohistochemical and Northern blot analyses. With anti-CD4 antibodies detecting different epitopes of the molecule, CD4+ neurons were defined in the cerebellum, thalamus, and pons. CD4+ glial cells were identified in the thalamus and pons. CD4-specific mRNA was detected in all three subareas and in the hippocampus, while other subareas were negative. The CD4+ cells were negative with anti-T cell antibodies (anti-CD2 and anti-CD8), as well as with antimonocyte antibodies (M-M 522 and M-M 42).

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References

    1. J Neurochem. 1978 Dec;31(6):1375-91 - PubMed
    1. Science. 1986 Nov 28;234(4780):1120-3 - PubMed
    1. J Neurochem. 1984 Oct;43(4):1061-7 - PubMed
    1. Nature. 1984 Dec 20-1985 Jan 2;312(5996):763-7 - PubMed
    1. Nature. 1984 Dec 20-1985 Jan 2;312(5996):767-8 - PubMed

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