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. 2019 May 2;19(1):36.
doi: 10.1186/s12880-018-0287-z.

Low-grade Myofibroblastic sarcoma: clinical and imaging findings

Lu Wang  1 , Ling-Xia Li  2 , De-Qiang Chen  3 , Lin Yang  3 , Shu-Kui Li  1 , Cai Cheng  4
Affiliations

Low-grade Myofibroblastic sarcoma: clinical and imaging findings

Lu Wang et al. BMC Med Imaging. .

Abstract

Background: Low-grade myofibroblastic sarcoma (LGMS) is a rare type of tumor. Previous research has paid much attention to reporting pathological analyses of LGMS. However, only few systematic clinical and/or radiological studies have been conducted.

Methods: This study recruited 14 cases (8 males and 6 females) of LGMS. X-ray or computer tomography (CT) scan were performed on 11 cases. MRI was performed on 5 cases.

Results: X-Ray and CT scan: Five cases developed LGMS in bones, including 3 cases in the distal femur, 1 in the right shoulder blade, and another 1 in the right inferior ramus. Massive infiltrative and vermiform bone destruction with poorly-circumscribed lesion margins and partial soft tissue masses were observed. The other 9 cases were developed in soft tissues. Out of them, 4 cases presented slightly irregular hyper- or lower-density masses with poorly-circumscribed margins. 2 cases presented massive calcification and ossification. Significant enhancement was observed in 1 case, while no obvious enhancement was seen in the other 2 cases. MRI: MR images of 5 cases revealed homogeneous iso- or hyper-signal intensity on T1WI and homogeneous or heterogeneous hyper-signal intensity on T2WI. Enhanced MRI revealed homogeneous enhancement in 2 cases and rim enhancement in 1 case.

Conclusions: Our findings show that LGMS is characterized by invasiveness, metastases and calcification. Different radiological tools should be employed to make an accurate diagnosis.

Keywords: Bones; CT; Low-grade myofibroblastic sarcoma (LGMS); MRI; Soft tissues.

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Conflict of interest statement

Ethics approval and consent to participate

Current study was approved by the Cang Zhou Central Hospital and need for signed informed consent was waived.

Competing interests

The authors declare that there is no conflict of interest regarding the publication of this paper.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
LGMS of the left breast. Mammography revealed an irregular high-density mass without calcification. No thickening and/or increase was observed in the surrounding breast trabeculae. and no swelling in the axillary lymph nodes
Fig. 2
Fig. 2
LGMS of the left distal femur. X-ray revealed osteolytic damage and cortex destruction of the left distal femur (a, b)
Fig. 3
Fig. 3
LGMS of the left lobe of the liver. CT scan revealed a low-density mass (a). The contrast-enhanced images showed heterogeneous enhancement at the early period (b). Delayed contrast-enhanced images revealed partially-filled concentric enhancement
Fig. 4
Fig. 4
X-ray revealed osteolytic damage and cortex destruction of the left distal femur (a). T2-weighted MRI revealed a heterogeneous high signal mass (b). Gadolinium-enhanced T1-weighted fat-suppression images revealed rim enhancement (c)
Fig. 5
Fig. 5
LGMS of the right shoulder. An irregular soft tissue mass in right shoulder with equal T1 and long T2 was observed (a, b). Enhanced MRI revealed a homogenous mass (c)
Fig. 6
Fig. 6
LGMS of the left thigh. CT scan revealed an irregular mass (a) with calcification inside (b)
Fig. 7
Fig. 7
X-ray revealed extensive damage and cortex destruction of the right remi inferior ossis pubis
Fig. 8
Fig. 8
LGMS of the right shoulder blade. Pre-operational CT scan revealed an irregular mass with massive calcification and ossification, and pulmonary metastasis
Fig. 9
Fig. 9
LGMS of the right partes iliaca. X-ray revealed an irregular area of ossification above the right greater trochanter of the femur
See this image and copyright information in PMC

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