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. 2019 May 7;73(17):2237-2239.
doi: 10.1016/j.jacc.2019.01.066.

Hypertrophic Cardiomyopathy in Noonan Syndrome Treated by MEK-Inhibition

Gregor Andelfinger, Christopher Marquis, Marie-Josée Raboisson, Yves Théoret, Stephan Waldmüller, Gesa Wiegand, Bruce D Gelb, Martin Zenker, Marie-Ange Delrue, Michael Hofbeck

Hypertrophic Cardiomyopathy in Noonan Syndrome Treated by MEK-Inhibition

Gregor Andelfinger et al. J Am Coll Cardiol. .
No abstract available

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References

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    1. Hernandez-Porras I, Fabbiano S, Schuhmacher AJ et al. K-RasV14I recapitulates Noonan syndrome in mice. Proceedings National Academy Sciences USA 2014;111:16395–400. - PMC - PubMed
    1. Wu X, Simpson J, Hong JH et al. MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation. J clinical investigation 2011;121:1009–25. - PMC - PubMed
    1. Khoury PR, Mitsnefes M, Daniels SR, Kimball TR. Age-specific reference intervals for indexed left ventricular mass in children. J Am Soc Echocardiography. 2009;22:709–14. - PubMed

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