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Review
. 2019 Sep 15:233:116440.
doi: 10.1016/j.lfs.2019.04.066. Epub 2019 Apr 30.

Long noncoding RNA/circular noncoding RNA-miRNA-mRNA axes in cardiovascular diseases

Ming Li  1 , Liwei Duan  1 , Yangxue Li  2 , Bin Liu  3
Affiliations
Review

Long noncoding RNA/circular noncoding RNA-miRNA-mRNA axes in cardiovascular diseases

Ming Li et al. Life Sci. .

Abstract

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Non-coding RNAs including long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs) have been reported to participate in pathological developments of CVDs through various mechanisms. Among them, the networks among lncRNAs/circRNAs, miRNAs, and mRNAs have recently attracted attention. Understanding the molecular mechanism could aid the discovery of therapeutic targets or strategies in CVDs including atherosclerosis, myocardial infarction (MI), hypertrophy, heart failure (HF) and cardiomyopathy. In this review, we summarize the latest research involving the lncRNA/circRNA-miRNA-mRNA axis in CVDs, with emphasis on the molecular mechanism.

Keywords: Cardiovascular disease; circRNA; lncRNA; miRNA.

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