Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Apr;37(4):715-7.
doi: 10.1212/wnl.37.4.715.

Treatment of amyotrophic lateral sclerosis with the TRH analog DN-1417

R J Hawley, R Kratz, R R Goodman, C B McCutchen, M Sirdofsky, P A Hanson

Treatment of amyotrophic lateral sclerosis with the TRH analog DN-1417

R J Hawley et al. Neurology. 1987 Apr.

Abstract

Thyrotropin-releasing hormone has been reported to increase strength in patients with amyotrophic lateral sclerosis (ALS). DN-1417 is an analog of thyrotropin-releasing hormone, which has less endocrinologic activity, but more anterior horn cell stimulating effect (with no "autorefractory state"). However, 2 mg DN-1417, IM twice a day for 1 month in an open-label trial, produced no objective improvement of strength in nine patients with ALS. No patient entered the double-blind, placebo-controlled phase of the trial.

PubMed Disclaimer

Publication types

LinkOut - more resources