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Review
. 2019 May;21(5):552-559.
doi: 10.1038/s41556-019-0319-0. Epub 2019 May 2.

RNA modifications regulating cell fate in cancer

Sylvain Delaunay  1   2 , Michaela Frye  3   4
Affiliations
Review

RNA modifications regulating cell fate in cancer

Sylvain Delaunay et al. Nat Cell Biol. 2019 May.

Abstract

The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributor to cancer. By modulating cell survival, differentiation, migration and drug resistance, RNA modifications add another regulatory layer of complexity to most aspects of tumourigenesis.

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References

    1. Boccaletto, P. et al. MODOMICS: a database of RNA modification pathways. 2017 update. Nucleic Acids Res. 46, D303–D307 (2018). - PubMed - DOI
    1. Helm, M. & Motorin, Y. Detecting RNA modifications in the epitranscriptome: predict and validate. Nat. Rev. Genet. 18, 275–291 (2017). - PubMed - DOI
    1. Frye, M., Jaffrey, S. R., Pan, T., Rechavi, G. & Suzuki, T. RNA modifications: what have we learned and where are we headed? Nat. Rev. Genet. 17, 365–372 (2016). - PubMed - DOI
    1. Dominissini, D. et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485, 201–206 (2012). - PubMed - DOI
    1. Dominissini, D. et al. The dynamic N 1-methyladenosine methylome in eukaryotic messenger RNA. Nature 530, 441–446 (2016). - PubMed - PMC - DOI

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