Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Mar 26:2019:6518308.
doi: 10.1155/2019/6518308. eCollection 2019.

The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup

Beata Pucher  1 , Magdalena Sobieska  2 , Michal Grzegorowski  1 , Jaroslaw Szydlowski  1
Affiliations

The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup

Beata Pucher et al. Mediators Inflamm. .

Abstract

The aim of the study was to evaluate the inflammatory reaction in children with pseudocroup and compare it with other laryngological diseases according to the available literature data. The study group included 51 children hospitalized because of pseudocroup. The measurements of the acute phase proteins (APP), such as C-reactive protein (CRP), alpha-1-antitrypsin (AT), alpha-1-antichymotrypsin (ACT), alpha-1-acid glycoprotein (AGP), ceruloplasmin (Cp), transferrin (Tf), alpha-2-macroglobulin (A2M), and haptoglobin (Hp) were obtained at 3 time points. The glycosylation profiles of AGP, ACT, and Tf were completed. An increased AGP level was observed in girls. The AGP glycosylation revealed the advantage of the W0 variant over the W1 variant. W1 and W2 were decreased in boys. W3 emerged in boys. The Tf concentration and T4 variant were lower compared to the control group. The A2M level was lower after treatment. The Hp and AT levels were decreased a few weeks later. The ACT glycosylation revealed a decrease of the A4 variant in boys. In conclusion, the inflammatory reaction during pseudocroup was of low intensity. The APP glycosylation suggested a chronic process. In a follow-up investigation, no normalization of the parameters was noted, but signs of persistent inflammation were observed.

PubMed Disclaimer

References

    1. Rankin I., Wang S. M., Waters A., Clement W. A., Kubba H. The management of recurrent croup in children. The Journal of Laryngology and Otology. 2013;127(5):494–500. doi: 10.1017/S0022215113000418. - DOI - PubMed
    1. Penezić A., Ivkić M., Ivkić B., Baudoin T. Subglottic laryngitis—changes in therapy approach over the past 20 years. Auris Nasus Larynx. 2015;42(5):390–395. doi: 10.1016/j.anl.2015.03.004. - DOI - PubMed
    1. Smith D. K., McDermott A., Sullivan J. F. Croup: diagnosis and management. American Family Physician. 2018;97(9):575–580. - PubMed
    1. Kwong K., Hoa M., Coticchia J. M. Recurrent croup presentation, diagnosis, and management. American Journal of Otolaryngology. 2007;28(6):401–407. doi: 10.1016/j.amjoto.2006.11.013. - DOI - PubMed
    1. Peltola V., Heikkinen T., Ruuskanen O. Clinical courses of croup caused by influenza and parainfluenza viruses. The Pediatric Infectious Disease Journal. 2002;21(1):76–78. doi: 10.1097/00006454-200201000-00020. - DOI - PubMed

MeSH terms