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Review
. 2018 Oct;45(5):311-316.
doi: 10.1159/000492949. Epub 2018 Sep 24.

Neonatal Alloimmune Neutropenia

Leendert Porcelijn  1 , Masja de Haas  1   2   3
Affiliations
Review

Neonatal Alloimmune Neutropenia

Leendert Porcelijn et al. Transfus Med Hemother. 2018 Oct.

Abstract

Neonatal alloimmune neutropenia (NAIN, NAIN or NIN) is a neutrophil blood group antagonism, analogous to hemolytic disease of the fetus and newborn (HDFN) and fetal/neonatal alloimmune thrombocytopenia (FNAIT). A limited number of prospective screening studies showed that granulocyte-specific antibodies were detectable in 0.35-1.1% of random postnatal maternal samples and that the incidence of NAIN was below 0.1%. Symptoms vary from none to mild skin infections, omphalitis or more severe infections like pneumonia, sepsis, and meningitis. Treatment of neonatal infection with antibiotics and granulocyte-colony stimulating factor is advised.

Keywords: Fetal alloimmune thrombocytopenia; Hemolytic disease of the newborn; Neonatal alloimmune neutropenia.

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References

    1. Slobody LB, Abramson H, LS Jr. Agranulocytosis of the newborn infant. JAMA. 1950;142:25. - PubMed
    1. Lehndorff H. Transitorische Granulocytopenie beim Neugcborenen. Helv. Paediat. Acta. 1951;6:173. - PubMed
    1. Lalezari P, Nussbaum M, Gelman S, Spaet T. Neonatal neutropenia due to maternal immunization. Blood. 1960;15:236–243. - PubMed
    1. Lalezari P, Radel E. Neutrophil-specific antigens: immunology and clinical significance. Semin Hematol. 1974;11:281–290. - PubMed
    1. Lalezari P, Murphy GB, Allen FH., Jr NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia. J Clin Invest. 1971;50:1108–1115. - PMC - PubMed