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. 2019 Mar 31:2019:7064328.
doi: 10.1155/2019/7064328. eCollection 2019.

Risk Factors for Predicting Lymph Nodes Posterior to Right Recurrent Laryngeal Nerve (LN-prRLN) Metastasis in Thyroid Papillary Carcinoma: A Meta-Analysis

Cunfu Li  1 , Jun Xiang  2   3 , Yunjun Wang  2   3
Affiliations

Risk Factors for Predicting Lymph Nodes Posterior to Right Recurrent Laryngeal Nerve (LN-prRLN) Metastasis in Thyroid Papillary Carcinoma: A Meta-Analysis

Cunfu Li et al. Int J Endocrinol. .

Abstract

Objective: To evaluate the risk factors for predicting lymph nodes (LN) posterior to right recurrent laryngeal nerve metastasis in thyroid papillary carcinoma.

Methods: PubMed, PMC, EMBASE, and the Cochrane Library were systematically searched for articles published spanning 30/06/2009-30/8/2018 using multiple search terms. Thirteen articles involving 10,014 patients were reviewed in our meta-analysis. Stata 15.1 software was used for the meta-analysis.

Results: The rate of LN posterior to right recurrent laryngeal nerve (LN-prRLN) metastasis was 8.65%. Univariate analysis showed that age (P = 0.001), gender (P < 0.001), tumour size (P < 0.001), lateral LN metastasis (P < 0.001), extrathyroidal invasion (P < 0.001), multifocality (P = 0.005), capsule invasion (P < 0.001), tumour location (P = 0.076), lymph nodes anterior to right recurrent laryngeal nerve (LN-arRLN) metastasis (P < 0.001), and central LN metastasis (P < 0.001) were significantly associated with the increased incidence of LN-prRLN metastasis in thyroid papillary carcinoma.

Conclusion: PTC patients aged <45, male, and with tumours > 1 cm, lateral LN metastasis, extrathyroidal invasion, multifocality, capsule invasion, LN-arRLN metastasis, or central LN metastasis were significantly correlated with lymph nodes posterior to right recurrent laryngeal nerve metastasis, indicating LN-prRLN dissection.

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Figures

Figure 1
Figure 1
Risk of bias.
Figure 2
Figure 2
Forest plot for metastasis according to age.
Figure 3
Figure 3
Forest plot for metastasis according to gender.
Figure 4
Figure 4
Forest plot for metastasis according to tumour size < 1 cm vs. tumour size ≥ 1 cm.
Figure 5
Figure 5
Forest plot for metastasis according to tumour size ≤ 1 cm vs. tumour size > 1 cm.
Figure 6
Figure 6
Forest plot for metastasis according to multifocality.
Figure 7
Figure 7
Forest plot for metastasis according to capsule invasion.
Figure 8
Figure 8
Forest plot for metastasis according to extrathyroidal invasion.
Figure 9
Figure 9
Forest plot for metastasis according to lateral LN metastasis.
Figure 10
Figure 10
Forest plot for metastasis according to LN-arRLN metastasis.
Figure 11
Figure 11
Forest plot for metastasis according to central LN.
See this image and copyright information in PMC

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