Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Apr 14;7(7):1241-1245.
doi: 10.3889/oamjms.2019.264. eCollection 2019 Apr 15.

Hypertension after Kidney Transplantation: Clinical Significance and Therapeutical Aspects

Galina Severova-Andreevska  1 , Ilina Danilovska  1 , Aleksandar Sikole  1 , Zivko Popov  2   3 , Ninoslav Ivanovski  3   4
Affiliations
Review

Hypertension after Kidney Transplantation: Clinical Significance and Therapeutical Aspects

Galina Severova-Andreevska et al. Open Access Maced J Med Sci. .

Abstract

Most of the kidney transplanted patients develop arterial hypertension after renal transplantation. Together with very well-known and usual risk factors, post-transplant hypertension contributes to the whole cardiovascular morbidity and mortality in the kidney transplant population. The reasons of post-transplant hypertension are factors related to donors and recipients, immunosuppressive therapy like Calcineurin Inhibitors (CNI) and surgery procedures (stenosis and kinking of the renal artery and ureteral obstruction). According to Eighth National Committee (JNC 8) recommendations, blood pressure > 140/90 mmHg is considered as hypertension. The usual antihypertensive drugs used for the control of hypertension are Calcium channel blockers (CCB), Angiotensin-converting enzyme (ACE) inhibitors, Angiotensin -II receptor blockers (ARB), B- blockers and diuretics. Follow the KDIGO guidelines the target blood pressure < 140/90 mmHg for patients without proteinuria and < 125/75 mmHg in patients with proteinuria is recommended. Better control of post-transplant hypertension improves the long-term graft and patient's survival.

Keywords: Antihypertensive drugs; Arterial hypertension; Kidney transplant recipients; Review article.

PubMed Disclaimer

References

    1. Naele J, Smith A. Cardiovascular risk factors following renal transplant. World J Transplant. 2015;5:183–195. https://doi.org/10.5500/wjt.v5.i4.183 PMid:26722646 PMCid:PMC4689929. - PMC - PubMed
    1. Kono K, Fujii H, Nakai K, et al. Relationship Between Type of Hypertension and Renal Arteriosclerosis in Chronic Glomerular Disease. Kidney Blood Press Res. 2014;41:374–383. https://doi.org/10.1159/000443440 PMid:27327274. - PubMed
    1. Stoumpos S, Jardien A, Mark P. Cardiovascular morbidity and mortality after kidney transplantation. Transplant Int. 2015;28:10–21. https://doi.org/10.1111/tri.12413 PMid:25081992. - PubMed
    1. Svensson M, Jardine A, Fellstrom B, et al. Prevention of cardiovascular disease after renal transplantation. CO-Transplantation. 2012;17(4):393–400. https://doi.org/10.1097/MOT.0b013e3283560a3b. - PubMed
    1. Konstantopoulou AS, Konstantopoulou PS, Paapargyriou Ik, et al. Masked, white coat and sustaned hypertenson :comparison of target organ damage and psychometric parameters. Journal of Human Hypertension. 2010;24:151–157. https://doi.org/10.1038/jhh.2009.55 PMid:19571827. - PubMed

LinkOut - more resources