Survey and analysis of the nutritional status in hospitalized patients with malignant gastric tumors and its influence on the quality of life

Zeng Qing Guo¹, Jia Mi Yu¹, Wei Li², Zhen Ming Fu³, Yuan Lin⁴, Ying Ying Shi⁵, Wen Hu⁶, Yi Ba⁷, Su Yi Li⁸, Zeng Ning Li⁹, Kun Hua Wang¹⁰, Jing Wu¹¹, Ying He¹², Jia Jun Yang¹³, Cong Hua Xie¹⁴, Xin Xia Song¹⁵, Gong Yan Chen¹⁶, Wen Jun Ma¹⁷, Su Xia Luo¹⁸, Zi Hua Chen¹⁹, Ming Hua Cong²⁰, Hu Ma²¹, Chun Ling Zhou²², Wei Wang²³, Qi Luo²⁴, Yong Mei Shi²⁵, Yu Mei Qi²⁶, Hai Ping Jiang²⁷, Wen Xian Guan²⁸, Jun Qiang Chen²⁹, Jia Xin Chen³⁰, Yu Fang³¹, Lan Zhou³², Yong Dong Feng³³, Rong Shao Tan³⁴, Tao Li³⁵, Jun Wen Ou³⁶, Qing Chuan Zhao³⁷, Jian Xiong Wu³⁸, Li Deng², Xin Lin³⁹, Liu Qing Yang⁴⁰, Mei Yang¹, Chang Wang², Chun Hua Song⁴¹, Hong Xia Xu⁴², Han Ping Shi⁴³; Investigation on the Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group

Affiliations

¹ Department of Medical Oncology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, 350014, Fujian, China.
² Cancer Center of the First Hospital of Jilin University, Changchun, 130021, Jilin, China.
³ Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
⁴ Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
⁵ Department of Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, Guangdong, China.
⁶ Department of Clinical Nutrition, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.
⁷ Department of Gastrointestinal Oncology, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
⁸ Department of Nutrition and Metabolism of Oncology, Affiliated Provincial Hospital of Anhui Medical University, Hefei, 230031, Anhui, China.
⁹ Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, 050031, Hebei, China.
¹⁰ Department of Gastrointestinal Surgery, Institute of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China.
¹¹ Department of Clinical Nutrition, The First People's Hospital of Kashi, Xinjiang, 844000, China.
¹² Department of Clinical Nutrition, Chongqing General Hospital, Chongqing, 400014, China.
¹³ Department of Colorectal and Anal Surgery, Huizhou Municipal Central Hospital, Huizhou, 516001, Guangdong, China.
¹⁴ Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, China.
¹⁵ Department of Oncology, Xingtai People's Hospital, Hebei Medical University, Xingtai, 054031, Hebei, China.
¹⁶ The First Department of the Tumor Hospital of Harbin Medical University, Harbin, 150085, Heilongjiang, China.
¹⁷ Department of Nutrition, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, China.
¹⁸ Department of Oncology, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, Henan, China.
¹⁹ Department of General Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
²⁰ Comprehensive Oncology Department, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, 100021, China.
²¹ Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China.
²² The Fourth Affiliated Hospital, Harbin Medical University, Harbin, 150001, Heilongjiang, China.
²³ Cancer Center, The First People's Hospital of Foshan, Foshan, 528000, Guangdong, China.
²⁴ Department of Gastrointestinal Tumor Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, Fujian, China.
²⁵ Department of Nutrition, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
²⁶ Department of Nutrition, Tianjin Third Central Hospital, Tianjin, 300170, China.
²⁷ Department of Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, Guangdong, China.
²⁸ Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu, China.
²⁹ Department of Gastrointestinal Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
³⁰ Department of Radiation and Medical Oncology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
³¹ Department of Clinical Nutrition, Peking University Cancer Hospital and Institute, Beijing, 100142, China.
³² Department of Nutrition, Tumor Hospital of Yunnan Province, Third Affiliated Hospital of Kunming Medical College, Kunming, 650118, Yunnan, China.
³³ Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
³⁴ Department of Nutrition, Guangzhou Red Cross Hospital, Guangzhou, 510220, Guangdong, China.
³⁵ Department of Radiotherapy, , School of Medicine, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, 610041, Sichuan, China.
³⁶ Department of Clinical Nutrition, Clifford Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510632, Guangdong, China.
³⁷ Department of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shanxi, China.
³⁸ Department of Hepatobiliary Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
³⁹ Department of Nutrition, Daping Hospital & Research Institute of Surgery, Third Military Medical University, Chongqing, 400042, China.
⁴⁰ Department of Gastrointestinal Surgery/Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, No.10 Tieyi Road, Haidian District, Beijing, 100038, China.
⁴¹ Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China. songch16@163.com.
⁴² Department of Nutrition, Daping Hospital & Research Institute of Surgery, Third Military Medical University, Chongqing, 400042, China. 1225743226@qq.com.
⁴³ Department of Gastrointestinal Surgery/Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, No.10 Tieyi Road, Haidian District, Beijing, 100038, China. shihp@vip.163.com.

PMID: 31049672
PMCID: PMC6882767
DOI: 10.1007/s00520-019-04803-3

Observational Study

Survey and analysis of the nutritional status in hospitalized patients with malignant gastric tumors and its influence on the quality of life

Zeng Qing Guo et al. Support Care Cancer. 2020 Jan.

. 2020 Jan;28(1):373-380.

doi: 10.1007/s00520-019-04803-3. Epub 2019 May 3.

Authors

Affiliations

¹ Department of Medical Oncology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, 350014, Fujian, China.
² Cancer Center of the First Hospital of Jilin University, Changchun, 130021, Jilin, China.
³ Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
⁴ Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
⁵ Department of Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, Guangdong, China.
⁶ Department of Clinical Nutrition, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.
⁷ Department of Gastrointestinal Oncology, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
⁸ Department of Nutrition and Metabolism of Oncology, Affiliated Provincial Hospital of Anhui Medical University, Hefei, 230031, Anhui, China.
⁹ Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, 050031, Hebei, China.
¹⁰ Department of Gastrointestinal Surgery, Institute of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China.
¹¹ Department of Clinical Nutrition, The First People's Hospital of Kashi, Xinjiang, 844000, China.
¹² Department of Clinical Nutrition, Chongqing General Hospital, Chongqing, 400014, China.
¹³ Department of Colorectal and Anal Surgery, Huizhou Municipal Central Hospital, Huizhou, 516001, Guangdong, China.
¹⁴ Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, China.
¹⁵ Department of Oncology, Xingtai People's Hospital, Hebei Medical University, Xingtai, 054031, Hebei, China.
¹⁶ The First Department of the Tumor Hospital of Harbin Medical University, Harbin, 150085, Heilongjiang, China.
¹⁷ Department of Nutrition, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, China.
¹⁸ Department of Oncology, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, Henan, China.
¹⁹ Department of General Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
²⁰ Comprehensive Oncology Department, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, 100021, China.
²¹ Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China.
²² The Fourth Affiliated Hospital, Harbin Medical University, Harbin, 150001, Heilongjiang, China.
²³ Cancer Center, The First People's Hospital of Foshan, Foshan, 528000, Guangdong, China.
²⁴ Department of Gastrointestinal Tumor Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, Fujian, China.
²⁵ Department of Nutrition, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
²⁶ Department of Nutrition, Tianjin Third Central Hospital, Tianjin, 300170, China.
²⁷ Department of Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, Guangdong, China.
²⁸ Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu, China.
²⁹ Department of Gastrointestinal Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
³⁰ Department of Radiation and Medical Oncology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
³¹ Department of Clinical Nutrition, Peking University Cancer Hospital and Institute, Beijing, 100142, China.
³² Department of Nutrition, Tumor Hospital of Yunnan Province, Third Affiliated Hospital of Kunming Medical College, Kunming, 650118, Yunnan, China.
³³ Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
³⁴ Department of Nutrition, Guangzhou Red Cross Hospital, Guangzhou, 510220, Guangdong, China.
³⁵ Department of Radiotherapy, , School of Medicine, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, 610041, Sichuan, China.
³⁶ Department of Clinical Nutrition, Clifford Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510632, Guangdong, China.
³⁷ Department of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shanxi, China.
³⁸ Department of Hepatobiliary Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
³⁹ Department of Nutrition, Daping Hospital & Research Institute of Surgery, Third Military Medical University, Chongqing, 400042, China.
⁴⁰ Department of Gastrointestinal Surgery/Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, No.10 Tieyi Road, Haidian District, Beijing, 100038, China.
⁴¹ Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China. songch16@163.com.
⁴² Department of Nutrition, Daping Hospital & Research Institute of Surgery, Third Military Medical University, Chongqing, 400042, China. 1225743226@qq.com.
⁴³ Department of Gastrointestinal Surgery/Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, No.10 Tieyi Road, Haidian District, Beijing, 100038, China. shihp@vip.163.com.

PMID: 31049672
PMCID: PMC6882767
DOI: 10.1007/s00520-019-04803-3

Abstract

Background/objectives: The assessment of nutritional status and the quality of life in patients with gastric cancer has become one of the important goals of current clinical treatment. The purpose of this study was to assess the nutritional status in hospitalized gastric cancer patients by using patient-generated subjective global assessment (PG-SGA) and to analyze the influence of nutritional status on the patients' quality of life (QOL).

Methods: We reviewed the pathological diagnosis of gastric cancer for 2322 hospitalized patients using PG-SGA to assess their nutritional status and collected data on clinical symptoms, the anthropometric parameters (height, weight, body mass index (BMI), mid-arm circumference (MAC), triceps skin-fold thickness (TSF), and hand-grip strength (HGS). We also collected laboratory data (prealbumin, albumin, hemoglobin) within 48 h after the patient was admitted to the hospital. The 30-item European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) was used for QOL assessment in all patients.

Results: By using PG-SGA, we found 80.4% of the patients were malnourished (score ≥ 4) and 45.1% of the patients required urgent nutritional support (score ≥ 9). In univariate analysis, old age (> 65 years, p < 0.001), female (p = 0.007), residence in a village (p = 0.004), a lower level of education (p < 0.001), and self-paying (p < 0.001) were indicated as risk factors of patients with gastric cancer to be suffering from severe malnutrition. There was a negative correlation between PG-SGA and various nutritional parameters (p < 0.05). The quality of life was significantly different in gastric cancer patients with different nutritional status (p < 0.01).

Conclusion: Malnutrition of hospitalized patients with gastric cancer in China is common and seriously affects the patients' quality of life. The nutritional status should be evaluated in a timely manner and reasonable nutritional intervention should be provided as soon as possible. The PG-SGA was fit for using as a clinical nutrition assessment method, being worthy of clinical application.

Keywords: Gastric cancer; Malnutrition; Patient-generated subjective global assessment (PG-SGA); Quality of life.

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References

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Survey and analysis of the nutritional status in hospitalized patients with malignant gastric tumors and its influence on the quality of life

Affiliations

Survey and analysis of the nutritional status in hospitalized patients with malignant gastric tumors and its influence on the quality of life

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Research Materials