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Comment
. 2019 May;286(10):1838-1840.
doi: 10.1111/febs.14851. Epub 2019 May 3.

A new approach to discovery of S100 protein heterodimers

Velia Garcia  1 , Walter J Chazin  1
Affiliations
Comment

A new approach to discovery of S100 protein heterodimers

Velia Garcia et al. FEBS J. 2019 May.

Abstract

S100 proteins are a sub-family of EF-hand calcium binding proteins that form very similar, unique dimer structures. Although the possibility has been known for many years, no systematic study of the formation of S100 protein heterodimers has been reported. Shaw and coworkers demonstrate the application of a new approach that provides an in-depth evaluation of the distribution of S100 protein homo- and heterodimer and show that the prevalence of heterodimers may be much higher than previously anticipated.

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Figures

Figure 1.
Figure 1.. Structural features of S100 proteins.
Upper left panel shows a helix-turn-helix EF-hand Ca2+ binding motif (left) and an EF-hand domain (right) (PDB entry 2H61). The lower panel shows the integration of two EF-hand domains in the S100A8/S100A8 homodimer (left) (PDB entry 1MR8) and the S100A8/S100A9 heterodimer (right) (PDB 1XK4).
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