Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 May 3:8:e46561.
doi: 10.7554/eLife.46561.

Comment on 'The distribution of antibiotic use and its association with antibiotic resistance'

Koen B Pouwels  1   2 , Christopher C Butler  3 , Julie V Robotham  1   2
Affiliations
Comment

Comment on 'The distribution of antibiotic use and its association with antibiotic resistance'

Koen B Pouwels et al. Elife. .

Abstract

We are writing to comment on the recent study by Olesen et al., 2018 on antibiotic use and antibiotic resistance.

Keywords: E. coli; S. pyogenes; antibiotic resistance; antibiotic use; antimicrobial; bacteria; epidemiology; global health; infectious disease; microbiology.

PubMed Disclaimer

Conflict of interest statement

KP, CB, JR No competing interests declared

Figures

Figure 1.
Figure 1.. Repeat use tends to be more positively associated with resistance than first use.
Each point represents a pathogen–antibiotic combination. The position of the points show the two coefficients from the regressions. The units of the coefficients are proportion resistant per annual claim per 10 people. Error bars show 95% confidence intervals.
See this image and copyright information in PMC

Comment in

Comment on

References

    1. Baym M, Stone LK, Kishony R. Multidrug evolutionary strategies to reverse antibiotic resistance. Science. 2016;351:aad3293. doi: 10.1126/science.aad3292. - DOI - PMC - PubMed
    1. Chatterjee A, Modarai M, Naylor NR, Boyd SE, Atun R, Barlow J, Holmes AH, Johnson A, Robotham JV. Quantifying drivers of antibiotic resistance in humans: a systematic review. The Lancet Infectious Diseases. 2018;18:e368–e378. doi: 10.1016/S1473-3099(18)30296-2. - DOI - PubMed
    1. Coenen S, Goossens H. Antibiotic treatment failure in primary care. Bmj. 2014;349:g5970. doi: 10.1136/bmj.g5970. - DOI - PubMed
    1. Dolk FCK, Pouwels KB, Smith DRM, Robotham JV, Smieszek T. Antibiotics in primary care in England: which antibiotics are prescribed and for which conditions? Journal of Antimicrobial Chemotherapy. 2018;73:ii2–ii10. doi: 10.1093/jac/dkx504. - DOI - PMC - PubMed
    1. Enne VI, Livermore DM, Stephens P, Hall LMC. Persistence of sulphonamide resistance in Escherichia coli in the UK despite national prescribing restriction. The Lancet. 2001;357:1325–1328. doi: 10.1016/S0140-6736(00)04519-0. - DOI - PubMed

MeSH terms

Substances