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Comment
. 2019 May 2;74(3):418-420.
doi: 10.1016/j.molcel.2019.04.017.

Histone Serotonylation: Can the Brain Have "Happy" Chromatin?

Jamie N Anastas  1 , Yang Shi  2
Affiliations
Comment

Histone Serotonylation: Can the Brain Have "Happy" Chromatin?

Jamie N Anastas et al. Mol Cell. .

Abstract

Recent work from Farrelly et al. (2019) indicates that histone tails can be serotonylated, suggesting a previously unappreciated direct mechanism of potential crosstalk between bioactive amines and the epigenome.

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Figures

Figure 1.
Figure 1.. Histone Serotonylation by Transglutaminase 2
High levels of nuclear serotonin (5-HT) lead to TGM2-dependent serotonylation of the histone H3 tail at glutamine 5 (H3Q5(5HT)), which co-occurs with lysine 4 trimethylation (H3K4me3). H3K4me3/H3Q5(5-HT) double-modified chromatin is found at promoters and correlates with gene transcription.
See this image and copyright information in PMC

Comment on

  • Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.
    Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H 3rd, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I. Farrelly LA, et al. Nature. 2019 Mar;567(7749):535-539. doi: 10.1038/s41586-019-1024-7. Epub 2019 Mar 13. Nature. 2019. PMID: 30867594 Free PMC article.

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