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. 2019 Apr 30;24(9):1686.
doi: 10.3390/molecules24091686.

A New Macrodiolide and Two New Polycyclic Chromones from the Fungus Penicillium sp. SCSIO041218

Jingxia Huang  1 , Jianglian She  2 , Xiliang Yang  3 , Juan Liu  4 , Xuefeng Zhou  5 , Bin Yang  6
Affiliations

A New Macrodiolide and Two New Polycyclic Chromones from the Fungus Penicillium sp. SCSIO041218

Jingxia Huang et al. Molecules. .

Abstract

A new macrodiolide, mangrovlide A (1) and two new polycyclic chromones, penixanthones C (2) and D (3), as well as four other known compounds (4-7), have been isolated from the mangrove sediment derived fungus Penicillium sp. SCSIO041218, cultured in the 0.25% NaCl rice substrate. The structures of the new compounds were determined by analysis of the NMR and MS spectroscopic data. Compound 1 possesses a 10-membered macrodiolide unit, while 2 and 3 are chromones with an unprecedented 6/6/6/5 polycyclic skeleton. Compounds 1-7 were evaluated for their cytotoxicities, while all the compounds displayed weak or no activity.

Keywords: Penicillium sp.; chromone; macrodiolide; marine fungus; penixanthone.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structures of compounds 1–7.
Figure 2
Figure 2
Key HMBC and 1H–1H COSY correlations of compounds 1 and 2.
Figure 3
Figure 3
NOESY correlations of compound 2.
See this image and copyright information in PMC

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