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. 2019 May 3;19(1):417.
doi: 10.1186/s12885-019-5637-x.

Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland

Xingyu Niu  1 , Qigen Fang  2 , Fei Liu  3
Affiliations

Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland

Xingyu Niu et al. BMC Cancer. .

Abstract

Background: Prognostic factors for parotid mucoepidermoid carcinoma (MEC) usually include disease grade, tumor stage, node stage, perineural invasion, and lymphovascular invasion. But the role of intraparotid nodes (IPNs) remains unclear, therefore, the study aimed to analyze the significance of IPNs in predicting recurrence in parotid MEC.

Methods: One hundred and ninety patients were included for analysis finally. Data regarding demography, pathological characteristics, IPN metastasis, TNM stage, follow up was collected and evaluated. The recurrence-free survival (RFS) was the main study endpoint.

Results: A total of 47 (24.7%) patients had IPN metastasis, and the IPN metastasis was significantly related to tumor stage, pathologic N stage, lymph-vascular invasion, perineural invasion, and disease grade. Recurrence occurred in 34 (17.9%) patients. For patients without IPN metastasis, the 10-year RFS rate was 88%, for patients with IPN metastasis, the 10-year RFS rate was 54%, the difference was significant (p < 0.001). Further Cox model analysis confirmed the independence of IPN metastasis in predicting the prognosis.

Conclusion: The IPN metastasis is relatively common in parotid MEC, it is significantly related to tumor stage and disease grade, IPN metastasis means worse recurrence-free survival.

Keywords: Intraparotid node; Mucoepidermoid carcinoma; Parotid cancer; Prognosis; Recurrence.

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Conflict of interest statement

Ethics approval and consent to participate

Our study was approved by the Zhengzhou University institutional research committee, and an informed consent agreement for medical research before initial treatment was achieved for all participants, and all experiments were performed in accordance with the Declaration of Helsinki.

Consent for publication

All the material came from our cancer center, and the publish consent have been obtained from all the patients.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Recurrence-free survival rate in patients with or without intraparotid node metastasis (p < 0.001)
See this image and copyright information in PMC

References

    1. Terhaard CH, Lubsen H, Van der Tweel I. Salivary gland carcinoma: independent prognostic factors for locoregional control, distant metastases, and overall survival: results of the Dutch head and neck oncology cooperative group. Head Neck. 2004;26:681–692. doi: 10.1002/hed.10400. - DOI - PubMed
    1. Barnes LEJRP, Sidransky D. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC. IARC: Lyon; 2005.
    1. Barnes LEJ, Reichart P, Sidransky D. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC. IARC: Lyon; 2005.
    1. Szewczyk M, Golusiński P, Pazdrowski J, Pieńkowski P, Marszałek S, Sygut J, Golusiński W. Patterns of treatment failure in salivary gland cancers. Rep Pract Oncol Radiother. 2018;23:260–265. doi: 10.1016/j.rpor.2018.05.004. - DOI - PMC - PubMed
    1. Nisa L, Borner U, Dür C, Arnold A, Giger R. Recurrent parotid gland carcinoma: how effective is salvage surgery? Eur Arch Otorhinolaryngol. 2018;275:507–13。. doi: 10.1007/s00405-017-4829-8. - DOI - PubMed

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