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. 1987 Feb;31(2):346-8.
doi: 10.1128/AAC.31.2.346.

In vivo synergism of roxithromycin (RU 965) and interferon against Toxoplasma gondii

J M Hofflin, J S Remington

In vivo synergism of roxithromycin (RU 965) and interferon against Toxoplasma gondii

J M Hofflin et al. Antimicrob Agents Chemother. 1987 Feb.

Abstract

We investigated the activity of roxithromycin (RU 965) and gamma interferon alone and in combination in a murine model of toxoplasmic encephalitis. Roxithromycin at a dosage of 35 or 50 mg per mouse per day decreased mortality. Gamma interferon alone significantly prolonged time to death. When combined, the two agents were remarkably synergistic.

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