Current status of insulin degludec in type 1 and type 2 diabetes based on randomized and observational trials

Abstract

Insulin degludec is a new ultra-long-action basal insulin. Using treat-to-target protocols, controlled trials have shown comparable HbA_1c reductions with insulin degludec and comparators in both type 1 and type 2 diabetes. Most studies identify, however, better control of fasting plasma glucose with insulin degludec vs. either insulin glargine U100 or detemir, and all have consistently demonstrated clinically relevant decreases in (nocturnal) hypoglycaemic episodes. These characteristics have provided added therapeutic value for insulin degludec in clinical practice. Thus, the aim of this review is to discuss, within the context of randomized and observational studies, the clinical effects of insulin degludec use in type 1 and type 2 diabetes.

Keywords: Fasting plasma glucose; HbA(1c); Hypoglycaemia; Insulin degludec; Insulin glargine U100; Insulin glargine U300; Type 1 diabetes; Type 2 diabetes.