Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Feb;108(2):429-438.
doi: 10.1002/jbm.b.34399. Epub 2019 May 6.

Synthesis and assessment of metallic ion migration through a novel calcium carbonate coating for biomedical implants

Le Thi Bang  1 , Luimar C Filho  1 , Håkan Engqvist  1 , Wei Xia  1 , Cecilia Persson  1
Affiliations

Synthesis and assessment of metallic ion migration through a novel calcium carbonate coating for biomedical implants

Le Thi Bang et al. J Biomed Mater Res B Appl Biomater. 2020 Feb.

Abstract

Titanium (Ti) implants are commonly regarded as well accepted by the body. However, metal ion release is still a cause for concern. A small decrease in pH, which can be caused by inflammation, may produce a large increase in the corrosion rate of Ti implants. Coating the alloy with a buffer layer could have a significant protective effect. In this study, a calcium carbonate coating was developed on commercially pure Ti and a Ti-6Al-4V alloy through a hydrothermal treatment of previously NaOH-treated surfaces in calcium-citric acid chelate complexes. The results showed that a superstructured calcite coating layer formed on the Ti substrate after treatment at 170°C for 3 hr. The coating was approx. 1 μm thick and covered the substrate surface uniformly. When prolonging the hydrothermal treatment from 5 hr to 24 hr, the rhombohedral structure of calcite was observed in addition to the superstructure of calcite. Dissolution test results showed no significant differences in solution pH between the coated- and un-coated samples. However, the CaCO3 coating reduced by approx. 2-5 times the Ti and V ion release from the substrate as compared to the uncoated material, at pH 4. CaCO3 and hydroxyapatite (HA) coatings gave nonsignificant effects at neutral pH although the HA coating showed a trend for better results at the longer time points. The reduction in metal ion release from the substrate and the buffering ability of the CaCO3 coating encourage further studies on this coating for clinical applications.

Keywords: calcium carbonate coating; ion release; protective barrier; titanium.

PubMed Disclaimer

References

REFERENCES

    1. Ahmed, R. A., Fekry, A. M., & Farghali, R. A. (2013). A study of calcium carbonate/multiwalled-carbon nanotubes/chitosan composite coatings on Ti-6Al-4V alloy for orthopedic implants. Applied Surface Science, 285, Part B, 309-316.
    1. Aizenberg, J., Weiner, S., & Addadi, L. (2003). Coexistence of amorphous and crystalline calcium carbonate in skeletal tissues. Connective Tissue Research, 44(1), 20-25.
    1. Barrere, F., van der Valk, C. M., Dalmeijer, R. A., van Blitterswijk, C. A., de Groot, K., & Layrolle, P. (2003). In vitro and in vivo degradation of biomimetic octacalcium phosphate and carbonate apatite coatings on titanium implants. Journal of Biomedical Materials Research. Part A, 64, 378-387.
    1. Browne, M., & Gregson, P. J. (1995). Metal ion release from wear particles produced by Ti-6Al-4V and Co-Cr alloy surfaces articulating against bone. Materials Letters, 24, 1-6.
    1. Clarke, S. A., Walsh, P., Maggs, C. A., & Buchanan, F. (2011). Designs from the deep: Marine organisms for bone tissue engineering. Biotechnology Advances, 29, 610-617.

Publication types

LinkOut - more resources