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Meta-Analysis
. 2019 May 6;19(1):383.
doi: 10.1186/s12879-019-4012-5.

Seroprevalence and trend of human immunodeficiency virus among blood donors in Ethiopia: a systematic review and meta-analysis

Henok Mulugeta  1 , Getenet Dessie  2 , Fasil Wagnew  3 , Dube Jara  4 , Cheru Tesema Leshargie  5 , Ayenew Negesse  6
Affiliations
Meta-Analysis

Seroprevalence and trend of human immunodeficiency virus among blood donors in Ethiopia: a systematic review and meta-analysis

Henok Mulugeta et al. BMC Infect Dis. .

Abstract

Background: Blood transfusion is one of the routine therapeutic interventions in hospitals that can be lifesaving. However, this intervention is related to several transfusion-related infections. The human immunodeficiency virus (HIV) is one of the major public health problems associated with blood transfusion. The objective of this systematic review and meta-analysis is to estimate seroprevalence and trend of human immunodeficiency virus among blood donors in Ethiopia.

Methods: Studies on the prevalence of human immunodeficiency virus among blood donors published until 2017 were accessed by conducting a detailed search on PubMed, Cochrane Library, Google Scholar, EMBASE and CINAHL databases using the keywords:-"Seroprevalence" AND "trend" AND "HIV" OR "human" AND "immunodeficiency" AND "virus" OR "human immunodeficiency virus" AND "blood donors" OR "blood donors" OR "Ethiopia". The quality of each article was assessed using a modified version of the Newcastle-Ottawa Scale. Meta-analysis was carried out using a random-effects method. All statistical analyses were done using STATA version 11 software.

Result: The estimated pooled seroprevalence of human immunodeficiency virus among blood donors in Ethiopia was 2.69% (95% CI (1.79-3.58%)). The overall seroprevalence of human immunodeficiency virus infection showed a significant decline trend from 2004 to 2016.

Conclusion: The overall seroprevalence of human immunodeficiency virus among blood donors in Ethiopia was high. Routine screening of donor blood for transfusion-transmissible infections is essential for ensuring the safety of blood transfusion.

Keywords: Blood donor; Ethiopia; Human immunodeficiency virus; Seroprevalence.

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The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Flowchart of study selection for seroprevalence of HIV among blood donors
Fig. 2
Fig. 2
Forest plot showing the pooled seroprevalence of HIV among blood donors
Fig. 3
Fig. 3
Subgroup analysis by regions on the seroprevalence of HIV among blood donors
Fig. 4
Fig. 4
Funnel plot to test the publication bias in the 11 studies
Fig. 5
Fig. 5
Result of sensitivity analysis of the 11 studies
Fig. 6
Fig. 6
Trend of HIV prevalence among blood donors in Ethiopia from 2004 to 2016
See this image and copyright information in PMC

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