Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Jun;20(6):668-669.
doi: 10.1038/s41590-019-0387-0.

Heavy metal protease takes a tiki torch to HIV assembly

Una O'Doherty  1 , Eric O Freed  2
Affiliations
Comment

Heavy metal protease takes a tiki torch to HIV assembly

Una O'Doherty et al. Nat Immunol. 2019 Jun.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests

The authors declare no competing interests.

Figures

Fig. 1 |
Fig. 1 |. HIV-1 replication is blocked at multiple stages in resting CD4+ T cells.
a, Major steps in the HIV-1 replication cycle, including attachment and entry of the virus, reverse transcription, import into the nucleus, integration of viral DNA, expression of viral genes, export of RNA, particle assembly, incorporation of Env, and particle budding and maturation. The steps in red font have been shown before to occur inefficiently in resting CD4+ T cells relative to that in activated CD4+ T cells (as discussed in the text). CXCR4 and CCR5, co-receptors; Pol, HIV polymerase; PIC, pre-integration complex. b, Proposed model for the degradation of Gag at the plasma membrane by the Tiki-family metalloprotease TRABD2A (by Liang et al.). In this model, TRABD2A-induced degradation of Gag prevents the assembly of viral particles in resting CD4+ T cells and their release from those cells.
See this image and copyright information in PMC

Comment on

References

    1. Siliciano JD et al. Nat. Med 9, 727 – 728 (2003). - PubMed
    1. Wiegand A et al. Proc. Natl Acad. Sci. USA 114, E3659 – E3668 (2017). - PMC - PubMed
    1. Baxter AE, O’Doherty U & Kaufmann DE Retrovirology 15, 18 (2018). - PMC - PubMed
    1. Liang G et al. Nat. Immunol 10.1038/s41590-019-0385-2 (2019). - DOI - PubMed
    1. Freed EO Nat. Rev. Microbiol 13, 484 – 496 (2015). - PMC - PubMed