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Review
. 2019 Aug;300(2):239-249.
doi: 10.1007/s00404-019-05181-1. Epub 2019 May 6.

Type-II endometrial cancer: role of adipokines

Kusuma Kumari Garikapati  1 , V V V Ravi Kiran Ammu  1 , Praveen T Krishnamurthy  2 , Pavan Kumar Chintamaneni  1 , Sai Kiran S S Pindiprolu  1
Affiliations
Review

Type-II endometrial cancer: role of adipokines

Kusuma Kumari Garikapati et al. Arch Gynecol Obstet. 2019 Aug.

Abstract

Background: Type-II endometrial cancer is an estrogen independent and one of the most lethal types of cancer having poor prognosis. Adipokines play a crucial role in the triggering Type-II EMC. In addition, adipokines modulators, therefore, may have beneficial effects in the treatment of Type-II endometrial cancer, which was clinically evidenced.

Areas covered: This review presents the role of various adipokines involved and also the suitable modulators to treat Type-II endometrial cancer.

Conclusion: In the present review, we try to discuss the role of individual adipokines in the pathogenesis of Type-II endometrial cancer, and also the possible beneficial effects of adipokines modulator in the treatment of Type-II endometrial cancer.

Keywords: Adipokine modulators; Adipokines; Adiponectin; Cancer; Endometrial cancer; Leptin; Resistin; Type-II EMC; Visfatin.

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