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Comment
. 2019 Nov 27;69(12):2236-2237.
doi: 10.1093/cid/ciz378.

Genetic Evidence That Naive T Cells Can Contribute Significantly to the Human Immunodeficiency Virus Intact Reservoir: Time to Re-evaluate Their Role

Emmanuele Venanzi Rullo  1   2 , LaMont Cannon  1 , Marilia Rita Pinzone  1 , Manuela Ceccarelli  1   2 , Giuseppe Nunnari  2 , Una O'Doherty  1
Affiliations
Comment

Genetic Evidence That Naive T Cells Can Contribute Significantly to the Human Immunodeficiency Virus Intact Reservoir: Time to Re-evaluate Their Role

Emmanuele Venanzi Rullo et al. Clin Infect Dis. .
No abstract available

Keywords: HIV; memory; naive; reservoir.

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Figures

Figure 1.
Figure 1.
Genetic evidence that naive T cells contribute significantly to the replication-competent reservoir. A, The number of intact proviruses per million CD4+ T cells for both subjects was determined after 2 years on suppressive ART. By sorting PBMCs into TN cells (green), TCM cells (blue), and other subsets (gray), the numbers of intact proviruses in all of the subsets were determined. TN cells contributed more intact proviruses than TCM cells. B, The percentages of intact (teal) and defective (black) proviruses within the 2 subsets are shown. Abbreviations: ART, antiretroviral therapy; PBMC, peripheral blood mononuclear cell; TCM, central memory CD4+ T cells; TN, naive CD4+ T cells.
See this image and copyright information in PMC

Comment on

References

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