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Meta-Analysis
. 2019 Aug:46:64-73.
doi: 10.1016/j.smrv.2019.03.008. Epub 2019 Mar 28.

Functional brain alterations in acute sleep deprivation: An activation likelihood estimation meta-analysis

Nooshin Javaheripour  1 , Niloofar Shahdipour  2 , Khadijeh Noori  2 , Mojtaba Zarei  1 , Julia A Camilleri  3 , Angela R Laird  4 , Peter T Fox  5 , Simon B Eickhoff  6 , Claudia R Eickhoff  7 , Ivana Rosenzweig  8 , Habibolah Khazaie  9 , Masoud Tahmasian  1
Affiliations
Meta-Analysis

Functional brain alterations in acute sleep deprivation: An activation likelihood estimation meta-analysis

Nooshin Javaheripour et al. Sleep Med Rev. 2019 Aug.

Abstract

Sleep deprivation (SD) is a common problem in modern societies, which leads to cognitive dysfunctions including attention lapses, impaired working memory, hindering decision making, impaired emotional processing, and motor vehicle accidents. Numerous neuroimaging studies have investigated the neural correlates of SD, but these studies have reported inconsistent results. Thus, we aimed to identify convergent patterns of abnormal brain functions due to acute SD. Based on the preferred reporting for systematic reviews and meta-analyses statement, we searched the PubMed database and performed reference tracking and finally retrieved 31 eligible functional neuroimaging studies. Then, we applied activation estimation likelihood meta-analysis and found reduced activity mainly in the right intraparietal sulcus and superior parietal lobule. The functional decoding analysis using the BrainMap database indicated that this region is mostly related to visuospatial perception, memory and reasoning. The significant co-activation of this region using the BrainMap database were found in the left superior parietal lobule, intraparietal sulcus, bilateral occipital cortex, left fusiform gyrus and thalamus. This region also connected with the superior parietal lobule, intraparietal sulcus, insula, inferior frontal gyrus, precentral, occipital and cerebellum through resting-state functional connectivity in healthy subjects. Taken together, our findings highlight the role of superior parietal cortex in SD.

Keywords: ALE meta-analysis; Functional neuroimaging; Inferior parietal lobule; Intraparietal sulcus; Sleep deprivation; Superior parietal lobule.

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Conflict of interest statement

Conflicts of interest

The authors do not have any conflicts of interest to disclose.

Figures

Fig. 1.
Fig. 1.
Paper selection strategy flow chart based on preferred reporting items for systematic reviews and meta-analyses statement.
Fig. 2.
Fig. 2.
A) Convergence of decreased activity in SD compared to NS based on both task and resting-state fMRI experiments in the right intraparietal sulcus and superior parietal lobule. All activations are significant at P < 0.05 corrected for multiple comparisons using the family-wise error rate in cluster level (cFWE); B) behavioral characterization of the significant cluster (p < 0.05, corrected for multiple comparisons).
Fig. 3.
Fig. 3.
A) The results of task-based functional connectivity analysis of the seed obtained from ALE findings using the BrainMap dataset; B) the results of resting-state functional connectivity of the seeds obtained from ALE findings in a healthy participants’ dataset; C) conjunction analysis demonstrated regions significantly co-activated with the seed in both task-based and task-independent datasets (p < 0.05 corrected for multiple comparisons using the family-wise error rate in cluster level (cFWE)).
See this image and copyright information in PMC

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