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Randomized Controlled Trial
. 2019 Jan;35(3):212-220.
doi: 10.1017/S026646231900028X. Epub 2019 May 8.

Incorporating Household Spillovers in Cost Utility Analysis: A Case Study Using Behavior Change in COPD

Arjun Bhadhuri  1 , Hareth Al-Janabi  2 , Sue Jowett  2 , Kate Jolly  3
Affiliations
Randomized Controlled Trial

Incorporating Household Spillovers in Cost Utility Analysis: A Case Study Using Behavior Change in COPD

Arjun Bhadhuri et al. Int J Technol Assess Health Care. 2019 Jan.

Abstract

Objectives: It is important to capture all health effects of interventions in cost-utility analyses conducted under a societal or healthcare perspective. However, this is rarely done. Household spillovers (health effects on patients' other household members) may be particularly likely in the context of technologies and interventions to change behaviors that are interdependent in the household. Our objective was to prospectively collect outcome data from household members and illustrate how these can be included in a cost-utility analysis of a behavior change intervention in chronic obstructive pulmonary disease (COPD).

Methods: Data were collected from patients' household members (n = 153) alongside a randomized controlled trial of a COPD self-management intervention. The impact of the intervention on household members' EQ-5D-5L scores (primary outcome), was evaluated. Analyses were then carried out to estimate household members' quality-adjusted life-years (QALYs) and assess the impact of including these QALYs on cost-effectiveness.

Results: The intervention had a negligible spillover on household members' EQ-5D-5L scores (-0.007; p = .75). There were also no statistically significant spillovers at the 5 percent level in household member secondary outcomes. In the base-case model, the inclusion of household member QALYs in the incremental cost-effectiveness ratio (ICER) denominator marginally increased the ICER from GBP 10,271 (EUR 13,146) to GBP 10,991 (EUR 14,068) per QALY gained.

Conclusions: This study demonstrates it is feasible to prospectively collect and include household members' outcome data in cost utility analysis, although the study highlighted several methodological issues. In this case, the intervention did not impact significantly on household members' health or health behaviors, but inclusion of household spillovers may make a difference in other contexts.

Keywords: COPD; economic evaluation; informal care; spillovers.

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